Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.52 |
| ▸ | SPR | P35270 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KHK | P50053 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | GPR6 | P46095 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10366974 | 0.92 | HSD11B1 (0.56) | HSD11B1SPRKDM4EALDH1A1CNR1 | |
| SCHEMBL2851938 | 0.90 | SPR (0.56) | HSD11B1SPRKDM4EALDH1A1CNR1 | |
| SCHEMBL10364638 | 0.81 | NPC1 (0.59) | HSD11B1SPRKDM4EALDH1A1MAPT | |
| SCHEMBL3423825 | 0.81 | KDM4E (0.49) | HSD11B1SPRKDM4EALDH1A1CNR1 | |
| SCHEMBL3390177 | 0.81 | KDM4E (0.49) | HSD11B1SPRKDM4EALDH1A1CNR1 | |
| SCHEMBL10365365 | 0.81 | ALDH1A1 (0.69) | HSD11B1SPRKDM4EALDH1A1MAPT | |
| SCHEMBL2854105 | 0.81 | LMNA (0.58) | KDM4EALDH1A1CNR1CNR2MAPT | |
| SCHEMBL2859309 | 0.81 | POLB (0.61) | ALDH1A1MAPTSMN1; SMN2TP53POLB | |
| SCHEMBL10364982 | 0.81 | KDM4E (0.53) | HSD11B1SPRKDM4EALDH1A1CNR1 | |
| SCHEMBL2860624 | 0.80 | SPR (0.57) | HSD11B1SPRKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |