Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.45 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10364511 | 0.96 | HSD11B1 (0.53) | SPRALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL2860624 | 0.87 | SPR (0.57) | SPRALDH1A1KDM4ESMN1; SMN2HSD11B1 | |
| SCHEMBL2851938 | 0.86 | SPR (0.56) | SPRALDH1A1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL2852540 | 0.85 | KDM4E (0.66) | SPRALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL2853087 | 0.84 | MAPK11 (0.53) | ALDH1A1KDM4EHSD11B1LMNAMAPT | |
| SCHEMBL10364638 | 0.83 | NPC1 (0.59) | SPRALDH1A1KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL10367050 | 0.83 | ALDH1A1 (0.55) | ALDH1A1KDM4ESMN1; SMN2HPGDKMT2A | |
| SCHEMBL2852972 | 0.82 | SPR (0.52) | SPRALDH1A1KDM4ESMN1; SMN2NPSR1 | |
| SCHEMBL10366974 | 0.81 | HSD11B1 (0.56) | SPRALDH1A1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL2856953 | 0.81 | ALDH1A1 (0.53) | ALDH1A1KDM4ESMN1; SMN2HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |