Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CCR1 | P32246 | 1/20 | 0.45 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.45 |
| ▸ | MAP3K2 | Q9Y2U5 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2860624 | 0.86 | SPR (0.57) | SPRHSD11B1MAPTALDH1A1KDM4E | |
| SCHEMBL2851938 | 0.85 | SPR (0.56) | SPRHSD11B1ACHEMAPTNPC1 | |
| SCHEMBL2852540 | 0.85 | KDM4E (0.66) | SPRHSD11B1MAPTNPSR1ALDH1A1 | |
| SCHEMBL2856647 | 0.84 | MAPK11 (0.52) | HSD11B1ACHEMAPTNPC1RAB9A | |
| SCHEMBL2854367 | 0.82 | SPR (0.56) | SPRHSD11B1MAPTNPC1RAB9A | |
| SCHEMBL2856308 | 0.82 | SPR (0.51) | SPRHSD11B1NPC1RAB9AALDH1A1 | |
| SCHEMBL2854458 | 0.81 | ACHE (0.56) | HSD11B1ACHEMAPTNPC1RAB9A | |
| SCHEMBL10366974 | 0.80 | HSD11B1 (0.56) | SPRHSD11B1ACHEMAPTNPC1 | |
| SCHEMBL10364638 | 0.80 | NPC1 (0.59) | SPRHSD11B1MAPTNPC1RAB9A | |
| SCHEMBL10365365 | 0.80 | ALDH1A1 (0.69) | SPRHSD11B1MAPTNPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |