Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.72 |
| ▸ | EED | O75530 | 1/20 | 0.58 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.58 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.58 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.58 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2852637 | 0.91 | NR3C1 (0.64) | HPGDTP53MAPTP2RX7NPC1 | |
| SCHEMBL2856505 | 0.89 | TP53 (0.59) | HPGDEEDRBBP4SUZ12EZH2 | |
| SCHEMBL2854454 | 0.86 | HPGD (0.72) | HPGDEEDRBBP4SUZ12EZH2 | |
| SCHEMBL2856089 | 0.84 | HPGD (1.00) | HPGDEEDRBBP4SUZ12EZH2 | |
| SCHEMBL2850617 | 0.83 | HPGD (0.84) | HPGDEEDRBBP4SUZ12EZH2 | |
| SCHEMBL2856450 | 0.83 | HPGD (0.74) | HPGDEEDRBBP4SUZ12EZH2 | |
| SCHEMBL2850016 | 0.83 | KDM4E (0.65) | HPGDTP53MAPTP2RX7PKM | |
| SCHEMBL2605692 | 0.81 | HPGD (0.76) | HPGDEEDRBBP4SUZ12EZH2 | |
| SCHEMBL2858097 | 0.81 | P2RX7 (0.53) | HPGDTP53MAPTLMNAP2RX7 | |
| SCHEMBL10367090 | 0.79 | HPGD (0.72) | HPGDNPC1RAB9APKMMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |