Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 15/20 | 0.62 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2852816 | 0.89 | ACHE (0.59) | CCR1ACHEMAPTNPSR1KDM4E | |
| SCHEMBL2858942 | 0.86 | CCR1 (0.82) | CCR1ACHEHSP90AA1MAPTNPSR1 | |
| SCHEMBL2859933 | 0.86 | CCR1 (0.80) | CCR1HSP90AA1MAPTNPSR1 | |
| SCHEMBL2856514 | 0.85 | CCR1 (0.49) | CCR1AKR1B1ACHEHSP90AA1MAPT | |
| SCHEMBL2862276 | 0.85 | CCR1 (0.70) | CCR1HSP90AA1MAPTNPSR1KDM4E | |
| SCHEMBL2855062 | 0.85 | CCR1 (0.65) | CCR1ACHEMAPTNPSR1KDM4E | |
| SCHEMBL2852015 | 0.84 | CCR1 (0.63) | CCR1HSP90AA1MAPTNPSR1KDM4E | |
| SCHEMBL2860444 | 0.84 | CCR1 (0.60) | CCR1ACHEMAPTNPSR1KDM4E | |
| SCHEMBL2854425 | 0.82 | CCR1 (0.60) | CCR1MAPTKDM4EALDH1A1 | |
| SCHEMBL2852112 | 0.81 | CCR1 (0.68) | CCR1ACHEMAPTNPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |