Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | AGXT | P21549 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL395656 | 0.82 | CA4 (0.37) | — | |
| Hydrochloric Acid SCHEMBL28550630 | 0.74 | HTR1B (0.37) | TDP1L3MBTL1MAPK1KDM4ENPC1 | |
| SCHEMBL5498476 | 0.70 | CYP2A6 (0.43) | CYP2A6CYP1A2AGXTTDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL395658 | 0.70 | TSHR (0.33) | CYP1A2LMNACA1CA2 | |
| Hydrochloric Acid SCHEMBL5691147 | 0.70 | KDM4E (0.32) | CYP1A2LMNAKDM4E | |
| Hydrochloric Acid SCHEMBL7040551 | 0.70 | GABRA1 (0.31) | — | |
| Hydrochloric Acid SCHEMBL397297 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL28544998 | 0.68 | MEN1 (0.37) | CYP1A2MAPT | |
| Hydrochloric Acid SCHEMBL6304295 | 0.68 | ALDH1A1 (0.37) | CYP1A2TDP1HTTLMNAKDM4E | |
| Hydrochloric Acid SCHEMBL11026182 | 0.67 | SMN1; SMN2 (0.37) | CYP1A2HTTLMNASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112661892-B | Polymerization system and polymerization method for copolymerization of ethylene and cycloolefin and copolymer obtained by polymerization method | 中国石油化工股份有限公司 | 2022-10-21 | — | — | CN | claimed |
| CN-112661785-B | Naphthyloxy single metallocene transition metal compound, catalyst composition containing naphthoxy single metallocene transition metal compound and application of catalyst composition | 中国石油化工股份有限公司 | 2022-10-21 | — | — | CN | claimed |
| CN-112661886-B | Styrene polymerization system and polymerization method and obtained polystyrene | 中国石油化工股份有限公司 | 2022-12-13 | — | — | CN | disclosed |
| CN-112661892-B | Polymerization system and polymerization method for copolymerization of ethylene and cycloolefin and copolymer obtained by polymerization method | 中国石油化工股份有限公司 | 2022-10-21 | — | — | CN | disclosed |
| CN-112661785-B | Naphthyloxy single metallocene transition metal compound, catalyst composition containing naphthoxy single metallocene transition metal compound and application of catalyst composition | 中国石油化工股份有限公司 | 2022-10-21 | — | — | CN | disclosed |
| CN-112661892-A | Polymerization system and polymerization method for copolymerization of ethylene and cycloolefin and copolymer obtained by polymerization method | 中国石油化工股份有限公司 | 2021-04-16 | — | — | CN | disclosed |
| CN-112661785-A | Naphthyloxy single metallocene transition metal compound, catalyst composition containing naphthoxy single metallocene transition metal compound and application of catalyst composition | 中国石油化工股份有限公司 | 2021-04-16 | — | — | CN | disclosed |
| CN-112661886-A | Styrene polymerization system and polymerization method and obtained polystyrene | 中国石油化工股份有限公司 | 2021-04-16 | — | — | CN | disclosed |