SCHEMBL28546283

SCHEMBL28546283

CC(=O)NC1(C(C)C(=O)O)C=Cc2ccccc2C1

nearest known ligand 0.32

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 2/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
MEN1 O00255 1/20 0.32
LMNA P02545 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C19 P33261 1/20 0.32
KMT2A Q03164 1/20 0.32
NPC1 O15118 1/20 0.32
PGR P06401 1/20 0.32
CYP3A4 P08684 1/20 0.32
GAA P10253 1/20 0.32
PKM P14618 1/20 0.32
NFKB1 P19838 1/20 0.32
DRD1 P21728 1/20 0.32
HTT P42858 1/20 0.32
RAB9A P51151 1/20 0.32
NFKB2 Q00653 1/20 0.32
RELA Q04206 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32
CXCR5 P32302 3/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3004213 0.83 GHSR (0.36) MEN1KMT2ANPC1GAARAB9A
SCHEMBL9782897 0.73 KMT2A (0.32) TP53KMT2A
SCHEMBL29462779 0.69 SDCBP (0.33) SMN1; SMN2MEN1LMNAKMT2AHTT
SCHEMBL2920161 0.69 POLB (0.34) TP53MEN1LMNAKMT2AHDAC9
SCHEMBL8627219 0.69 SLC22A6 (0.43) SMN1; SMN2NFKB1RAB9AMTNR1AMTNR1B
SCHEMBL8627222 0.69 SLC22A6 (0.43) SMN1; SMN2NFKB1RAB9AMTNR1AMTNR1B
SCHEMBL9793274 0.67 CA1 (0.32)
SCHEMBL8068895 0.66 MAOA (0.35) CXCR5HDAC9
SCHEMBL28924809 0.65 HSD17B3 (0.35) MTNR1AMTNR1B
SCHEMBL7529245 0.64 CA1 (0.35) CXCR5HDAC9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108752232-B Synthetic method of alpha-quaternary carbon amino acid 四川大学 2021-03-19 CN disclosed