Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.36 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2858618 | 0.93 | ALDH1A1 (0.41) | ALDH1A1KDM4EMAPTSMN1; SMN2POLB | |
| SCHEMBL2854496 | 0.92 | P2RX7 (0.47) | ALDH1A1KDM4EMAPTTRPV1P2RX7 | |
| SCHEMBL2856697 | 0.90 | KDM4E (0.46) | ALDH1A1KDM4EMAPTSMN1; SMN2POLB | |
| SCHEMBL2848315 | 0.90 | TRPV1 (0.54) | ALDH1A1KDM4EMAPTTRPV1P2RX7 | |
| SCHEMBL2853186 | 0.87 | TRPV1 (0.41) | KDM4EMAPTTRPV1LMNAP2RX7 | |
| SCHEMBL2860303 | 0.87 | TRPV1 (0.39) | ALDH1A1KDM4EMAPTSMN1; SMN2TRPV1 | |
| SCHEMBL2854509 | 0.86 | KDM4E (0.50) | ALDH1A1KDM4EMAPTSMN1; SMN2POLB | |
| SCHEMBL2850252 | 0.86 | TRPV1 (0.40) | ALDH1A1KDM4ETRPV1LMNAP2RX7 | |
| SCHEMBL2859861 | 0.86 | TAAR1 (0.51) | ALDH1A1KDM4EMAPTSMN1; SMN2POLB | |
| SCHEMBL2860826 | 0.85 | KDM4E (0.43) | ALDH1A1KDM4EMAPTSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |