Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 13/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.35 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7098104 | 0.85 | NOTUM (0.44) | NOTUMKEAP1CYP1A2CYP2C9CHRNB2 | |
| SCHEMBL18367778 | 0.83 | NOTUM (0.41) | NOTUMMEN1LMNATHRBBLM | |
| SCHEMBL3863178 | 0.78 | NR1H2 (0.42) | NOTUMMAOA | |
| SCHEMBL8090136 | 0.78 | NR1H2 (0.42) | NOTUMMAOA | |
| SCHEMBL616911 | 0.77 | NOTUM (0.51) | NOTUMTDP1CYP1A2CYP2C9CHRNB2 | |
| SCHEMBL13106398 | 0.77 | NOTUM (0.49) | NOTUMLMNACYP1A2CYP2C9CHRNB2 | |
| SCHEMBL613201 | 0.76 | ALDH1A1 (0.51) | NOTUMMEN1LMNATHRBBLM | |
| SCHEMBL8109481 | 0.75 | ALDH1A1 (0.53) | NOTUMMEN1LMNATHRBBLM | |
| SCHEMBL28858824 | 0.75 | NOTUM (0.49) | NOTUMMEN1KMT2ATDP1KEAP1 | |
| SCHEMBL27883271 | 0.73 | ALDH1A1 (0.43) | NOTUMMEN1LMNATHRBBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210380548-A1 | Fused [1,2,4]Thiadiazine Derivatives Which Act as KAT Inhibitors of the MYST Family | CTXT PTY LIMITED (AU) | 2021-12-09 | — | — | US | disclosed |
| EP-3676266-A1 | FUSED [1,2,4]THIADIAZINE DERIVATIVES WHICH ACT AS KAT INHIBITORS OF THE MYST FAMILY | Ctxt Pty Ltd (AU) | 2020-07-08 | — | — | EP | disclosed |
| CN-106165684-B | Pesticidal compositions and methods relating thereto | 陶氏益农公司 | 2019-06-14 | — | — | CN | disclosed |
| WO-2019043139-A1 | FUSED [1,2,4]THIADIAZINE DERIVATIVES WHICH ACT AS KAT INHIBITORS OF THE MYST FAMILY | CTXT PTY LIMITED (AU) | 2019-03-07 | — | — | WO | disclosed |
| WO-2019043139-A1 | FUSED [1,2,4]THIADIAZINE DERIVATIVES WHICH ACT AS KAT INHIBITORS OF THE MYST FAMILY | CTXT PTY LIMITED (AU) | 2019-03-07 | — | — | WO | disclosed |
| CN-105025715-B | Pesticidal compositions and methods related thereto | 美国陶氏益农公司 | 2018-11-16 | — | — | CN | disclosed |
| CN-104981160-B | Pesticidal compositions and methods related thereto | 美国陶氏益农公司 | 2018-04-20 | — | — | CN | disclosed |
| CN-104981154-B | Pesticidal compositions and methods related thereto | 美国陶氏益农公司 | 2018-01-26 | — | — | CN | disclosed |
| CN-106413402-A | Hepatitis b core protein allosteric modulators | 美国印第安纳大学研究和技术公司 | 2017-02-15 | — | — | CN | disclosed |
| CN-106165684-A | Pesticidal compositions and methods relating thereto | 陶氏益农公司 | 2016-11-30 | — | — | CN | disclosed |
| CN-104981155-A | Pesticidal compositions and methods related thereto | DOW AGROSCIENCES LLC | 2015-10-14 | — | — | CN | disclosed |
| US-8263586-B2 | OXO bridged diazepan orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2012-09-11 | — | — | US | disclosed |
| US-20100227848-A1 | OXO BRIDGED DIAZEPAN OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2010-09-09 | — | — | US | disclosed |
| EP-1202961-B1 | ARYLSULFONAMIDO-SUBSTITUTED HYDROXAMIC ACID DERIVATIVES | NOVARTIS AG (CH) | 2010-01-20 | — | — | EP | disclosed |
| EP-2085379-A1 | Arylsulfonamido-substituted hydroxamic acid derivatives | Novartis AG (CH) | 2009-08-05 | — | — | EP | disclosed |
| CN-101500596-A | Macrocyclic oximino hepatitis C protease inhibitors | ENANTA PHARM INC (US) | 2009-08-05 | — | — | CN | disclosed |
| US-7138432-B1 | Arylsulfonamido-substituted hydroxamic acid derivatives | NOVARTIS AG (CH) | 2006-11-21 | — | — | US | disclosed |
| EP-1202961-A1 | ARYLSULFONAMIDO-SUBSTITUTED HYDROXAMIC ACID DERIVATIVES | Novartis AG (CH) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001010827-A1 | ARYLSULFONAMIDO-SUBSTITUTED HYDROXAMIC ACID DERIVATIVES | NOVARTIS AG (CH) | 2001-02-15 | — | — | WO | disclosed |
| EP-0010607-B1 | TRIAZOLYLSTYRYL COMPOUNDS AND THEIR USE AS WHITENERS FOR ORGANIC MATERIALS | BAYER AG (DE) | 1981-08-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210380548-A1 | Fused [1,2,4]Thiadiazine Derivatives Which Act as KAT Inhibitors of the MYST Family | KAT5, KAT6A, KAT2A | NOTUM 3650/4885MEN1 1280/4885LMNA 4612/4885 |
| US-20100227848-A1 | OXO BRIDGED DIAZEPAN OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, OXTR | NOTUM 3741/4885MEN1 1976/4885LMNA 3907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.