Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.54 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.51 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2850370 | 0.90 | DGAT2 (0.55) | DGAT2TAS1R3TAS1R1PDE4BEPHX2 | |
| SCHEMBL2859103 | 0.87 | EPHX2 (0.45) | DGAT2TAS1R3TAS1R1PDE4BEPHX2 | |
| SCHEMBL2852021 | 0.86 | DGAT2 (0.51) | DGAT2TAS1R3TAS1R1PDE4BEPHX2 | |
| SCHEMBL2850896 | 0.83 | DGAT2 (0.57) | DGAT2TAS1R3TAS1R1PDE4BEPHX2 | |
| SCHEMBL2856352 | 0.82 | DGAT2 (0.56) | DGAT2TAS1R3TAS1R1PDE4BEPHX2 | |
| SCHEMBL10364566 | 0.78 | KDM4E (0.52) | ALDH1A1HPGDMALT1MAPTKMT2A | |
| SCHEMBL2857544 | 0.77 | TSHR (0.45) | DGAT2TAS1R3TAS1R1PDE4BEPHX2 | |
| SCHEMBL2855742 | 0.76 | CCR1 (0.58) | HPGDGAAMEN1KMT2A | |
| SCHEMBL2857426 | 0.75 | CCR1 (0.55) | DGAT2ALDH1A1HPGDHTTNPSR1 | |
| SCHEMBL2852937 | 0.74 | KLKB1 (0.43) | DGAT2TAS1R3TAS1R1PDE4BEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |