Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2852021 | 0.88 | DGAT2 (0.51) | KLKB1PDE4BALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL2859103 | 0.87 | EPHX2 (0.45) | KLKB1PDE4BALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL2857544 | 0.84 | TSHR (0.45) | KLKB1PDE4BALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL2853809 | 0.82 | P2RX7 (0.49) | KLKB1PDE4BALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL2853175 | 0.82 | KLKB1 (0.43) | KLKB1PDE4BALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL2857917 | 0.81 | MAPT (0.42) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2853347 | 0.79 | TRPV1 (0.41) | ALDH1A1HPGDMAPT | |
| SCHEMBL2852635 | 0.78 | EPHX1 (0.44) | NPSR1MEN1KMT2A | |
| SCHEMBL2861682 | 0.77 | ALDH1A1 (0.48) | ALDH1A1TSHRHPGDSMN1; SMN2MEN1 | |
| SCHEMBL2857979 | 0.77 | TRPV1 (0.39) | MEN1KMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |