Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.49 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CCR1 | P32246 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2856352 | 0.92 | DGAT2 (0.56) | DGAT2MAPTKLKB1EPHX2PDE4B | |
| SCHEMBL2857426 | 0.89 | CCR1 (0.55) | DGAT2MAPTP2RX7ALDH1A1HPGD | |
| SCHEMBL2853809 | 0.86 | P2RX7 (0.49) | DGAT2MAPTKLKB1EPHX2PDE4B | |
| SCHEMBL2855224 | 0.85 | CCR1 (0.55) | DGAT2MAPTALDH1A1GAACCR1 | |
| SCHEMBL2850370 | 0.85 | DGAT2 (0.55) | DGAT2MAPTKLKB1EPHX2PDE4B | |
| SCHEMBL2858191 | 0.85 | CCR1 (0.56) | DGAT2P2RX7ALDH1A1CCR1NR3C1 | |
| SCHEMBL2856127 | 0.84 | CCR1 (0.64) | DGAT2MAPTKLKB1CCR1 | |
| SCHEMBL2860606 | 0.84 | CCR1 (0.53) | DGAT2MAPTP2RX7ALDH1A1HPGD | |
| SCHEMBL2852975 | 0.84 | CCR1 (0.55) | DGAT2MAPTALDH1A1HPGDHTT | |
| SCHEMBL2856282 | 0.83 | DGAT2 (0.54) | DGAT2MAPTKLKB1EPHX2PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |