Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.56 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.49 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2850896 | 0.92 | DGAT2 (0.57) | DGAT2KLKB1PDE4BTAS1R3TAS1R1 | |
| SCHEMBL2853175 | 0.86 | KLKB1 (0.43) | DGAT2KLKB1PDE4BTAS1R3TAS1R1 | |
| SCHEMBL2850370 | 0.84 | DGAT2 (0.55) | DGAT2KLKB1PDE4BTAS1R3TAS1R1 | |
| SCHEMBL2856282 | 0.82 | DGAT2 (0.54) | DGAT2KLKB1PDE4BTAS1R3TAS1R1 | |
| SCHEMBL2852021 | 0.81 | DGAT2 (0.51) | DGAT2KLKB1PDE4BTAS1R3TAS1R1 | |
| SCHEMBL2857426 | 0.80 | CCR1 (0.55) | DGAT2ALDH1A1NPSR1TSHRHPGD | |
| SCHEMBL2855701 | 0.78 | CCR1 (0.54) | DGAT2ALDH1A1KDM4ETRPC3 | |
| SCHEMBL2853809 | 0.78 | P2RX7 (0.49) | DGAT2KLKB1PDE4BTAS1R3TAS1R1 | |
| SCHEMBL10366447 | 0.78 | TRPC3 (0.62) | DGAT2ALDH1A1NPSR1HPGDPKM | |
| SCHEMBL2850316 | 0.78 | TP53 (0.59) | DGAT2ALDH1A1NPSR1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |