Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6738062 | 0.78 | ALDH1A1 (0.43) | ERN1ALDH1A1MAPTKDM4ECYP3A4 | |
| SCHEMBL10682999 | 0.67 | NQO1 (0.40) | ERN1ALDH1A1KDM4ECYP3A4KMT2A | |
| SCHEMBL15676522 | 0.66 | MEN1 (0.31) | KMT2ATDP1MEN1LMNA | |
| SCHEMBL5145863 | 0.66 | ERN1 (0.34) | ERN1PRKDCKMT2ATDP1MEN1 | |
| SCHEMBL9215364 | 0.63 | ALDH1A1 (0.62) | ERN1ALDH1A1MAPTKDM4ECYP3A4 | |
| SCHEMBL183545 | 0.63 | KMT2A (0.66) | ALDH1A1MAPTKDM4ECYP3A4ALOX15 | |
| SCHEMBL17320650 | 0.60 | MAPT (0.49) | ERN1ALDH1A1MAPTKDM4ECYP3A4 | |
| SCHEMBL15200988 | 0.60 | LMNA (0.58) | ALDH1A1MAPTKDM4ECYP3A4KMT2A | |
| SCHEMBL3644484 | 0.59 | ALDH1A1 (0.67) | ERN1ALDH1A1MAPTHSD17B10KMT2A | |
| Nitric Acid SCHEMBL11753070 | 0.59 | KMT2A (0.59) | ALDH1A1MAPTKDM4ECYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1746097-B1 | 1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them | AVENTIS PHARMA SA (FR) | 2010-01-13 | — | — | EP | disclosed |
| EP-1746097-A1 | 1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them | Aventis Pharma S.A. (FR) | 2007-01-24 | — | — | EP | disclosed |