Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | LAP3 | P28838 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | CES1 | P23141 | 3/20 | 0.39 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | ACP3 | P15309 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL788438 | 0.81 | LMNA (0.52) | LMNAPOLBMEN1KMT2ATSHR | |
| SCHEMBL9300577 | 0.79 | LMNA (0.46) | LMNAPOLBMEN1KMT2ATSHR | |
| SCHEMBL27884622 | 0.79 | LMNA (0.50) | LMNAPOLBMEN1KMT2ATSHR | |
| SCHEMBL8412291 | 0.76 | LMNA (0.43) | LMNAPOLBMEN1KMT2ATSHR | |
| SCHEMBL4930837 | 0.74 | CA2 (0.48) | LMNAPOLBMEN1KMT2ATSHR | |
| Biphenyl SCHEMBL27805026 | 0.70 | SRC (0.50) | LMNAPOLBMEN1KMT2ALAP3 | |
| SCHEMBL2989889 | 0.70 | LMNA (0.53) | LMNAPOLBMEN1KMT2ATSHR | |
| SCHEMBL2850978 | 0.69 | LAP3 (0.49) | LMNAPOLBMEN1KMT2ATSHR | |
| SCHEMBL27521919 | 0.69 | TSHR (0.45) | LMNAPOLBMEN1KMT2ATSHR | |
| SCHEMBL5802987 | 0.69 | TSHR (0.55) | LMNAPOLBMEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406910-B1 | PREPARATION METHODS OF DERIVATIVES OF BISPHOSPHONATES | UNIV PARIS 13 (FR) | 2010-01-13 | — | — | EP | disclosed |
| EP-1406910-A1 | NOVEL BISPHOSPHONATE DERIVATIVES, THEIR PREPARATION METHODS AND USES | Universite Paris 13 (FR) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003008425-A1 | NOVEL BISPHOSPHONATE DERIVATIVES, THEIR PREPARATION METHODS AND USES | UNIVERSITE PARIS 13 (FR) | 2003-01-30 | — | — | WO | disclosed |