Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2859098 | 0.92 | NPC1 (0.47) | KDM4EALDH1A1POLBSMN1; SMN2MAPT | |
| SCHEMBL2854509 | 0.86 | KDM4E (0.50) | KDM4EALDH1A1POLBSMN1; SMN2MAPT | |
| SCHEMBL2854824 | 0.82 | POLB (0.44) | KDM4EALDH1A1POLBSMN1; SMN2MAPT | |
| SCHEMBL2852488 | 0.82 | KDM4E (0.47) | KDM4EALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL2860253 | 0.82 | PLAAT3 (0.47) | KDM4EALDH1A1POLBSMN1; SMN2MAPT | |
| SCHEMBL2857936 | 0.82 | KDM4E (0.47) | KDM4EALDH1A1POLBSMN1; SMN2MAPT | |
| SCHEMBL2856562 | 0.82 | MAPT (0.48) | KDM4EALDH1A1POLBSMN1; SMN2MAPT | |
| SCHEMBL2860110 | 0.82 | KDM4E (0.47) | KDM4EALDH1A1POLBSMN1; SMN2MAPT | |
| SCHEMBL2855734 | 0.82 | ALDH1A1 (0.44) | ALDH1A1POLBSMN1; SMN2MAPTKMT2A | |
| SCHEMBL2854705 | 0.81 | ALDH1A1 (0.46) | KDM4EALDH1A1POLBSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |