SCHEMBL285727

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL285398	0.92	THRB (0.48)	THRBTSHRHPGDALDH1A1HIF1A
	SCHEMBL285406	0.91	THRB (0.47)	THRBTSHRHPGDALDH1A1HIF1A
	SCHEMBL285640	0.89	TSHR (0.49)	THRBTSHRHPGDALDH1A1HIF1A
	SCHEMBL285630	0.89	THRB (0.50)	THRBTSHRHPGDALDH1A1HIF1A
	SCHEMBL285335	0.85	THRB (0.53)	THRBTSHRALDH1A1HIF1ATP53
	SCHEMBL285356	0.83	THRB (0.48)	THRBTSHRHPGDALDH1A1HIF1A
	SCHEMBL718737	0.81	CYP2C19 (0.37)	THRBTSHRALDH1A1HIF1ACYP3A4
	SCHEMBL285289	0.80	POLB (0.41)	THRBTSHRALDH1A1HIF1ACHRM2
	SCHEMBL718425	0.80	KIF11 (0.36)	THRBTSHRALDH1A1HIF1ACYP3A4
	SCHEMBL10437472	0.77	THRB (0.56)	THRBTSHRHPGDALDH1A1HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.