Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 2/20 | 0.54 |
| ▸ | PDE2A | O00408 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.49 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.48 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2852200 | 0.92 | SPR (0.51) | SPRPDE2AALDH1A1MAPTMAPK1 | |
| SCHEMBL3391804 | 0.85 | SPR (0.55) | SPRALDH1A1MAPTGAAPOLB | |
| SCHEMBL3395550 | 0.85 | SPR (0.55) | SPRALDH1A1MAPTGAAPOLB | |
| SCHEMBL2079211 | 0.84 | SPR (0.67) | SPRPDE2AALDH1A1MAPTMAPK1 | |
| SCHEMBL2854713 | 0.83 | NTRK1 (0.49) | SPRPDE2AALDH1A1MAPTMAPK1 | |
| SCHEMBL2856262 | 0.81 | ALDH1A1 (0.59) | SPRALDH1A1MAPTMAPK1GAA | |
| SCHEMBL2854682 | 0.81 | ALDH1A1 (0.60) | SPRPDE2AALDH1A1MAPTPOLB | |
| SCHEMBL3390170 | 0.78 | SPR (0.68) | SPRPDE2AALDH1A1LMNANTRK1 | |
| SCHEMBL3394457 | 0.78 | SPR (0.68) | SPRPDE2AALDH1A1LMNANTRK1 | |
| SCHEMBL2850487 | 0.78 | HTT (0.48) | ALDH1A1MAPK1NTRK1TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |