Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
| ▸ | RAF1 | P04049 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4156310 | 0.81 | LTA4H (0.48) | SMN1; SMN2LTA4HTSHRCYP3A4 | |
| SCHEMBL901182 | 0.81 | MAOA (0.47) | SMN1; SMN2LMNALTA4HSCN9A | |
| SCHEMBL28564069 | 0.80 | GRM5 (0.36) | LMNATDP1CYP3A4 | |
| SCHEMBL8126363 | 0.80 | LMNA (0.61) | SMN1; SMN2LMNATDP1LTA4HFFAR4 | |
| SCHEMBL21630308 | 0.78 | SOS1 (0.38) | S1PR2SCN9A | |
| SCHEMBL21630305 | 0.78 | TEAD4 (0.44) | SMN1; SMN2TDP1 | |
| SCHEMBL21630390 | 0.78 | LTA4H (0.41) | SMN1; SMN2LTA4H | |
| SCHEMBL21630310 | 0.78 | MAPT (0.44) | LTA4HTSHR | |
| SCHEMBL921637 | 0.78 | S1PR2 (0.34) | S1PR2KDRLMNATDP1LTA4H | |
| SCHEMBL21630334 | 0.77 | PDE4A (0.40) | LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112574200-B | Small molecule inhibitors of BTK and/or mutant C481S of BTK | 安润医药科技（苏州）有限公司 | 2021-06-11 | — | — | CN | disclosed |
| CN-112574200-A | Small molecule inhibitors of BTK and/or mutant C481S of BTK | 安润医药科技（苏州）有限公司 | 2021-03-30 | — | — | CN | disclosed |