Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | STAT1 | P42224 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MYC | P01106 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28325052 | 0.85 | NPC1 (0.62) | LMNAMAPTSMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL10684744 | 0.84 | NPC1 (0.65) | LMNAMAPTSMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL5532619 | 0.84 | NPC1 (0.51) | LMNAMAPTHPGDALDH1A1NPC1 | |
| SCHEMBL6105727 | 0.83 | NPC1 (0.54) | LMNAMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL28529587 | 0.82 | LMNA (0.57) | LMNAMAPTSMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL28567564 | 0.81 | ALDH1A1 (0.50) | LMNAMAPTSMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL10607131 | 0.80 | AKR1C3 (0.53) | LMNAMAPTSMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL2612163 | 0.80 | NPC1 (0.54) | LMNAMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL28578595 | 0.79 | ALDH1A1 (0.51) | LMNAMAPTSMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL20587384 | 0.78 | NPC1 (0.71) | LMNAMAPTSMN1; SMN2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110256443-B | Indole derivative and preparation method thereof | 广州中医药大学(广州中医药研究院) | 2021-05-14 | — | — | CN | disclosed |