Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | HNF4A | P41235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14254609 | 1.00 | L3MBTL1 (0.35) | L3MBTL1RAB9ANPC1KDM4EHPGD | |
| SCHEMBL31043202 | 1.00 | L3MBTL1 (0.35) | L3MBTL1RAB9ANPC1KDM4EHPGD | |
| SCHEMBL4841739 | 1.00 | L3MBTL1 (0.35) | L3MBTL1RAB9ANPC1KDM4EHPGD | |
| SCHEMBL12786202 | 1.00 | L3MBTL1 (0.35) | L3MBTL1RAB9ANPC1KDM4EHPGD | |
| SCHEMBL29871051 | 1.00 | L3MBTL1 (0.35) | L3MBTL1RAB9ANPC1KDM4EHPGD | |
| SCHEMBL31642941 | 1.00 | L3MBTL1 (0.35) | L3MBTL1RAB9ANPC1KDM4EHPGD | |
| SCHEMBL14001438 | 0.94 | L3MBTL1 (0.34) | L3MBTL1RAB9ANPC1KDM4EHPGD | |
| SCHEMBL14075526 | 0.88 | UGT2B7 (0.40) | MEN1KMT2AABCG2CYP1A2TSHR | |
| SCHEMBL13296110 | 0.88 | UGT2B7 (0.40) | MEN1KMT2AABCG2CYP1A2TSHR | |
| SCHEMBL16193207 | 0.86 | L3MBTL1 (0.34) | L3MBTL1RAB9ANPC1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2943460-B1 | 6-CHLORO-3-(PHENYL-D5)-INDEN-1-ONE AND USE THEREOF | H LUNDBECK AS (DK) | 2020-02-12 | — | — | EP | disclosed |
| US-9309165-B2 | 6-chloro-3-(phenyl-d5)-inden-1-one and use thereof | H. LUNDBECK A/S (DK) | 2016-04-12 | — | — | US | disclosed |
| US-20150336867-A1 | 6-chloro-3-(phenyl-d5)-inden-1-one and use thereof | H. LUNDBECK A/S (DK) | 2015-11-26 | — | — | US | disclosed |
| EP-2227454-B1 | PROCESS FOR THE PREPARATION OF AN ENANTIOMERIC TRISUBSTITUTED 3,4-DIHYDRO-ISOQUINOLINE DERIVATIVE | ACTELION PHARMACEUTICALS LTD (CH) | 2015-09-30 | — | — | EP | disclosed |
| US-8314238-B2 | Process for the preparation of an enantiomeric trisubstituted 3,4-dihydro-isoquinoline derivative | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-11-20 | — | — | US | disclosed |
| US-8314238-B2 | Process for the preparation of an enantiomeric trisubstituted 3,4-dihydro-isoquinoline derivative | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-11-20 | — | — | US | disclosed |
| US-8247560-B2 | Trisubstituted 3,4-dihydro-1H-isoquinolin compound, process for its preparation, and its use | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-08-21 | — | — | US | disclosed |
| US-8247560-B2 | Trisubstituted 3,4-dihydro-1H-isoquinolin compound, process for its preparation, and its use | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-08-21 | — | — | US | disclosed |
| EP-2227455-B1 | TRISUBSTITUTED 3,4-DIHYDRO-1H-ISOQUINOLIN COMPOUND, PROCESS FOR ITS PREPARATION, AND ITS USE | ACTELION PHARMACEUTICALS LTD (CH) | 2011-10-12 | — | — | EP | disclosed |
| US-7863443-B2 | Phosphoramidite ligand and production method of allylic amine using the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-01-04 | — | — | US | disclosed |
| US-20100010226-A1 | TRISUBSTITUTED 3,4-DIHYDRO-1H-ISOQUINOLIN COMPOUND, PROCESS FOR ITS PREPARATION, AND ITS USE | IDORSIA PHARMACEUTICALS LTD (CH) | 2010-01-14 | — | — | US | disclosed |
| US-20100010226-A1 | TRISUBSTITUTED 3,4-DIHYDRO-1H-ISOQUINOLIN COMPOUND, PROCESS FOR ITS PREPARATION, AND ITS USE | IDORSIA PHARMACEUTICALS LTD (CH) | 2010-01-14 | — | — | US | disclosed |
| WO-2009083899-A2 | PROCESS FOR THE PREPARATION OF AN ENANTIOMERIC TRISUBSTITUTED 3,4-DIHYDRO-ISOQUINOLINE DERIVATIVE | ACTELION PHARMACEUTICALS LTD (CH) | 2009-07-09 | — | — | WO | disclosed |
| WO-2009083903-A1 | TRISUBSTITUTED 3,4-DIHYDRO-1H-ISOQUINOLIN COMPOUND, PROCESS FOR ITS PREPARATION, AND ITS USE | ACTELION PHARMACEUTICALS LTD (CH) | 2009-07-09 | — | — | WO | disclosed |
| US-20090054689-A1 | PHOSPHORAMIDITE LIGAND AND PRODUCTION METHOD OF ALLYLIC AMINE USING THE SAME | Carreira, Erick M. (CH) | 2009-02-26 | — | — | US | disclosed |
| US-20090054689-A1 | PHOSPHORAMIDITE LIGAND AND PRODUCTION METHOD OF ALLYLIC AMINE USING THE SAME | Carreira, Erick M. (CH) | 2009-02-26 | — | — | US | disclosed |
| US-20080227978-A1 | Converting a carbonyl group within a substrate to a chiral alcohol moiety by reacting the carbonyl containing substrate with an organoaluminium reagent in the presence of a Group 5-12 transition metal based catalyst which is complexed with a chiral ligand; excellent yields | THE UNIVERSITY OF NOTTINGHAM | 2008-09-18 | — | — | US | disclosed |
| US-20080227978-A1 | Converting a carbonyl group within a substrate to a chiral alcohol moiety by reacting the carbonyl containing substrate with an organoaluminium reagent in the presence of a Group 5-12 transition metal based catalyst which is complexed with a chiral ligand; excellent yields | THE UNIVERSITY OF NOTTINGHAM | 2008-09-18 | — | — | US | disclosed |
| US-20070259774-A1 | Enantioselective Phosphoramidite Compounds and Catalysts | YALE UNIVERSITY (US) | 2007-11-08 | — | — | US | disclosed |
| US-20070259774-A1 | Enantioselective Phosphoramidite Compounds and Catalysts | YALE UNIVERSITY (US) | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054689-A1 | PHOSPHORAMIDITE LIGAND AND PRODUCTION METHOD OF ALLYLIC AMINE USING THE SAME | ADH5, SELENOI, ADH1A | L3MBTL1 2667/4885RAB9A 4261/4885NPC1 4771/4885 |
| US-20100010226-A1 | TRISUBSTITUTED 3,4-DIHYDRO-1H-ISOQUINOLIN COMPOUND, PROCESS FOR ITS PREPARATION, AND ITS USE | CYP3A7, UGT1A7, CYP51A1 | L3MBTL1 4872/4885RAB9A 305/4885NPC1 347/4885 |
| US-20070259774-A1 | Enantioselective Phosphoramidite Compounds and Catalysts | AKR1C3, PCNA, AKR1C4 | L3MBTL1 1463/4885RAB9A 2571/4885NPC1 3697/4885 |
| US-20150336867-A1 | 6-chloro-3-(phenyl-d5)-inden-1-one and use thereof | CYP2D6, UGT1A6, IDO1 | L3MBTL1 1198/4885RAB9A 4250/4885NPC1 697/4885 |
| US-20080227978-A1 | Converting a carbonyl group within a substrate to a chiral alcohol moiety by reacting the carbonyl containing substrate with an organoaluminium reagent in the presence of a Group 5-12 transition metal based catalyst which is complexed with a chiral ligand; excellent yields | ADH5, ADH1C, CYP2E1 | L3MBTL1 3533/4885RAB9A 3968/4885NPC1 3683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.