Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CKS1B | P61024 | 2/20 | 0.47 |
| ▸ | SKP1 | P63208 | 2/20 | 0.47 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.43 |
| ▸ | DTYMK | P23919 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Aminopyridine SCHEMBL28443400 | 0.85 | GPR119 (0.55) | GPR119POLBCKS1BSKP1SKP2 | |
| SCHEMBL1088005 | 0.82 | L3MBTL1 (0.69) | GPR119POLBCKS1BSKP1SKP2 | |
| SCHEMBL29086062 | 0.80 | GPR119 (0.53) | GPR119POLBCKS1BSKP1SKP2 | |
| SCHEMBL28702489 | 0.80 | MAPK1 (0.51) | L3MBTL1KMT2A | |
| SCHEMBL14122068 | 0.80 | GPR119 (0.55) | GPR119POLBCKS1BSKP1SKP2 | |
| SCHEMBL3324042 | 0.79 | PLA2G1B (0.60) | GPR119GRM5HPGDMEN1KMT2A | |
| SCHEMBL3324037 | 0.79 | PLA2G1B (0.60) | GPR119GRM5HPGDMEN1KMT2A | |
| SCHEMBL406827 | 0.78 | GPR119 (0.62) | GPR119POLBHPGDUSP30 | |
| SCHEMBL7720432 | 0.77 | GPR119 (0.52) | GPR119POLBCKS1BSKP1SKP2 | |
| SCHEMBL29461540 | 0.77 | GPR119 (0.76) | GPR119POLBCKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113105475-B | Inhibitors of bruton's tyrosine kinase and methods of use thereof | 詹森药业有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-113105475-A | Inhibitors of bruton's tyrosine kinase and methods of use thereof | 詹森药业有限公司 | 2021-07-13 | — | — | CN | disclosed |