Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CCR1 | P32246 | 3/20 | 0.52 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.52 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.52 |
| ▸ | MAP3K2 | Q9Y2U5 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2852043 | 0.93 | KDM4E (0.70) | MAPTKDM4EALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL2858927 | 0.91 | KDM4E (0.61) | MAPTKDM4EALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL2853014 | 0.90 | KDM4E (0.60) | MAPTKDM4EALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL2852896 | 0.89 | KDM4E (0.63) | MAPTKDM4EALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL2857175 | 0.89 | MAPT (0.57) | MAPTKDM4EALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL2855132 | 0.89 | MAPT (0.57) | MAPTKDM4EALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL2855239 | 0.88 | ALDH1A1 (0.56) | MAPTKDM4EALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL2848312 | 0.87 | CCR1 (0.56) | MAPTKDM4EALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL2852102 | 0.84 | ALDH1A1 (0.67) | MAPTKDM4EALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL13513697 | 0.84 | ABCB1 (0.58) | MAPTKDM4EALDH1A1CCR1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |