Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.49 |
| ▸ | MAP3K2 | Q9Y2U5 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2850316 | 0.90 | TP53 (0.59) | ALDH1A1KDM4EMAPTDGAT2SMN1; SMN2 | |
| SCHEMBL2852043 | 0.90 | KDM4E (0.70) | ALDH1A1KDM4EMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL2858927 | 0.88 | KDM4E (0.61) | ALDH1A1KDM4EMAPTSMN1; SMN2POLB | |
| SCHEMBL2859017 | 0.88 | MAPT (0.69) | ALDH1A1KDM4EMAPTSMN1; SMN2POLB | |
| SCHEMBL2853014 | 0.87 | KDM4E (0.60) | ALDH1A1KDM4EMAPTSMN1; SMN2POLB | |
| SCHEMBL2851942 | 0.85 | NPC1 (0.64) | ALDH1A1KDM4EMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL2852633 | 0.84 | TAAR1 (0.57) | ALDH1A1KDM4EMAPTKMT2ATP53 | |
| SCHEMBL10366447 | 0.84 | TRPC3 (0.62) | ALDH1A1KDM4EMAPTDGAT2KMT2A | |
| SCHEMBL26965090 | 0.84 | ALDH1A1 (0.50) | ALDH1A1KDM4EMAPTDGAT2KMT2A | |
| SCHEMBL2848312 | 0.83 | CCR1 (0.56) | ALDH1A1KDM4EMAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |