SCHEMBL2860423

SCHEMBL2860423

CC(=O)Oc1ccnc(Cl)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 5/20 0.46
CYP3A4 P08684 4/20 0.46
KDM4E B2RXH2 6/20 0.42
ACHE P22303 2/20 0.42
SMARCA2 P51531 2/20 0.41
SMARCA4 P51532 2/20 0.41
GLA P06280 2/20 0.41
ALDH1A1 P00352 1/20 0.41
F2 P00734 1/20 0.41
HPGD P15428 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.40
RECQL P46063 1/20 0.40
MAPT P10636 3/20 0.40
TDP1 Q9NUW8 2/20 0.40
ABCB11 O95342 1/20 0.40
ESR1 P03372 1/20 0.40
ADRA2A P08913 1/20 0.40
CYP2C9 P11712 1/20 0.40
TSHR P16473 1/20 0.40
PDE4A P27815 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9319785 0.87 RECQL (0.41) KDM4ESMARCA2SMARCA4ALDH1A1RECQL
SCHEMBL9650144 0.83 RECQL (0.41) SMARCA2SMARCA4ALDH1A1RECQLHTT
SCHEMBL9324832 0.82 SMARCA2 (0.43) CYP3A4SMARCA2SMARCA4ALDH1A1RECQL
SCHEMBL15880529 0.81 MEN1 (0.52) KDM4ESMARCA2SMARCA4RECQLMEN1
SCHEMBL17669635 0.81 CCR1 (0.55) LMNACYP3A4KDM4EACHEGLA
SCHEMBL27703246 0.81 ELANE (0.49) SMARCA2SMARCA4
SCHEMBL9325940 0.81 RAB9A (0.53) LMNAKDM4EACHEALDH1A1HPGD
SCHEMBL27680292 0.81 ACHE (0.46) KDM4EACHESMARCA2SMARCA4GLA
SCHEMBL9670309 0.79 LMNA (0.47) LMNACYP3A4KDM4EACHEGLA
SCHEMBL7674985 0.79 LMNA (0.52) LMNACYP3A4KDM4EACHEGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116411037-A Preparation method of azacyclic ester compound 河南农业大学 2023-07-11 CN disclosed
CN-102199120-A Method for synthesizing 2,2'-bipyridine-4,4'-dicarboxylic acid UNIV LIAOCHENG 2011-09-28 CN disclosed
EP-1805141-B1 PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE MERCK SHARP & DOHME (GB) 2010-01-20 EP disclosed
EP-1805141-A1 PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE MERCK SHARP & DOHME LTD. (GB) 2007-07-11 EP disclosed
CN-1260227-C 5-membered ring heterocyclic compounds with nitrogen TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2006-06-21 CN disclosed
WO-2006043064-A1 PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE MERCK SHARP & DOHME LIMITED (GB) 2006-04-27 WO disclosed
CN-1413207-A 5-membered ring heterocyclic compounds with nitrogen TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-04-23 CN disclosed
CN-1279682-A bicyclic kinase inhibitors HOFFMANN LA ROCHE (CH) 2001-01-10 CN disclosed