Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Chloramphenicol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.97 |
| ▸ | TSHR | P16473 | 2/20 | 0.97 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.97 |
| ▸ | MARS2 | Q96GW9 | 1/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.97 |
| ▸ | RPLP1 | P05386 | 1/20 | 0.88 |
| ▸ | RPLP0 | P05388 | 1/20 | 0.88 |
| ▸ | RPS17 | P08708 | 1/20 | 0.88 |
| ▸ | RPSA | P08865 | 1/20 | 0.88 |
| ▸ | RPS2 | P15880 | 1/20 | 0.88 |
| ▸ | RPL35A | P18077 | 1/20 | 0.88 |
| ▸ | RPL7 | P18124 | 1/20 | 0.88 |
| ▸ | RPL17 | P18621 | 1/20 | 0.88 |
| ▸ | RPS4Y1 | P22090 | 1/20 | 0.88 |
| ▸ | RPS3 | P23396 | 1/20 | 0.88 |
| ▸ | RPS12 | P25398 | 1/20 | 0.88 |
| ▸ | RPL13 | P26373 | 1/20 | 0.88 |
| ▸ | RPL10 | P27635 | 1/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chloramphenicol SCHEMBL49057 | 0.99 | LMNA (1.00) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL537158 | 0.99 | LMNA (1.00) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL29557257 | 0.99 | LMNA (1.00) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL28181476 | 0.99 | LMNA (1.00) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL4295048 | 0.99 | LMNA (1.00) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL16111 | 0.99 | LMNA (1.00) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL4262903 | 0.99 | LMNA (1.00) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL11131056 | 0.97 | LMNA (0.97) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL41042 | 0.97 | LMNA (0.97) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL20531030 | 0.97 | LMNA (0.97) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109182566-B | Method for preventing and treating bacterial soft rot of canna edulis ker | 广东省农业科学院植物保护研究所 | 2021-07-20 | — | — | CN | disclosed |