SCHEMBL28617698

SCHEMBL28617698

COc1cc(NC=O)c(OC)cc1NC=O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 3/20 0.47
MAPT P10636 2/20 0.43
MAPK1 P28482 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
ALDH1A1 P00352 6/20 0.41
KDM4E B2RXH2 5/20 0.41
TSHR P16473 4/20 0.41
TDP1 Q9NUW8 1/20 0.41
OR51E2 Q9H255 1/20 0.39
GAA P10253 2/20 0.38
PRKDC P78527 1/20 0.38
PAX8 Q06710 1/20 0.36
HSD17B10 Q99714 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
CYP1A1 P04798 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP1B1 Q16678 1/20 0.36
GLA P06280 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28285145 0.96 KDM4E (0.48) HTTMAPTMAPK1NPSR1ALDH1A1
SCHEMBL11029210 0.88 KDM4E (0.44) HTTMAPTMAPK1NPSR1ALDH1A1
SCHEMBL7530972 0.84 KDM4E (0.53) MAPTALDH1A1KDM4EGAASMN1; SMN2
SCHEMBL27391515 0.81 ALDH1A1 (0.57) HTTMAPTMAPK1ALDH1A1KDM4E
SCHEMBL8901392 0.81 GAA (0.49) HTTMAPTNPSR1ALDH1A1KDM4E
SCHEMBL13696659 0.81 ALDH1A1 (0.51) HTTMAPTNPSR1ALDH1A1KDM4E
SCHEMBL1758614 0.80 ALDH1A1 (0.56) HTTMAPTMAPK1NPSR1ALDH1A1
SCHEMBL1758834 0.80 ACHE (0.50) MAPTMAPK1ALDH1A1KDM4ETSHR
SCHEMBL28389628 0.80 MAOB (0.49) HTTMAPTMAPK1NPSR1ALDH1A1
SCHEMBL2203559 0.80 ALDH1A1 (0.56) HTTMAPTALDH1A1OR51E2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113322057-A Adsorption inhibitor, preparation method and application thereof 中国石油化工股份有限公司 2021-08-31 CN claimed
CN-113322057-B Adsorption inhibitor, preparation method and application thereof 中国石油化工股份有限公司 2022-05-24 CN disclosed
CN-113322057-A Adsorption inhibitor, preparation method and application thereof 中国石油化工股份有限公司 2021-08-31 CN disclosed