Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 6/20 | 0.70 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.69 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.63 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12440407 | 0.87 | MCHR1 (0.75) | LTA4HMCHR1HRH3SIGMAR1ALDH1A1 | |
| SCHEMBL7403686 | 0.86 | LTA4H (0.70) | LTA4HMCHR1HRH3ALDH1A1KMT2A | |
| SCHEMBL14204982 | 0.86 | LTA4H (0.81) | LTA4HHRH3SIGMAR1KCNA5 | |
| SCHEMBL11251038 | 0.86 | GAA (0.55) | LTA4HMCHR1HRH3ALDH1A1GAA | |
| SCHEMBL7138419 | 0.84 | LTA4H (0.78) | LTA4HHRH3SIGMAR1 | |
| SCHEMBL5709502 | 0.84 | SIGMAR1 (0.60) | LTA4HMCHR1HRH3SIGMAR1ALDH1A1 | |
| SCHEMBL4528896 | 0.83 | MCHR1 (1.00) | MCHR1 | |
| SCHEMBL7140388 | 0.82 | LTA4H (1.00) | LTA4H | |
| SCHEMBL19692527 | 0.82 | DRD2 (0.58) | LTA4HHRH3SIGMAR1ALDH1A1MEN1 | |
| SCHEMBL30165633 | 0.82 | L3MBTL1 (0.66) | MCHR1HRH3ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109563071-B | Chemical compounds as inhibitors of the ATF4pathway | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-08-03 | — | — | CN | disclosed |