SCHEMBL28623583

SCHEMBL28623583

Nc1cccc(-c2cccc(Cl)c2)c1O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDO2 P48775 1/20 0.47
ALOX5 P09917 1/20 0.47
USP7 Q93009 1/20 0.47
DHFR P00374 1/20 0.46
PGR P06401 1/20 0.45
ESR2 Q92731 1/20 0.43
ADORA2A P29274 1/20 0.43
ADORA1 P30542 1/20 0.43
PIK3CA P42336 2/20 0.42
ALDH1A1 P00352 1/20 0.42
TSHR P16473 1/20 0.42
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
TAAR1 Q96RJ0 1/20 0.42
IKBKE Q14164 1/20 0.41
ALOX15 P16050 1/20 0.41
ALOX12 P18054 1/20 0.41
PDK2 Q15119 1/20 0.41
KDM4E B2RXH2 1/20 0.41
MAPT P10636 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL398850 0.82 ALDH1A1 (0.58) TDO2ALOX5DHFRPGRADORA2A
SCHEMBL29575632 0.82 ALDH1A1 (0.58) TDO2ALOX5DHFRPGRADORA2A
SCHEMBL3785880 0.81 MAP4K4 (0.50) USP7ALDH1A1KDM4EMAPTMAP4K4
SCHEMBL6250190 0.80 PIK3CA (0.45) TDO2ALOX5USP7DHFRPGR
SCHEMBL6261652 0.80 PGR (0.48) TDO2ALOX5USP7DHFRPGR
SCHEMBL21933948 0.79 ALDH1A1 (0.50) TDO2ALOX5DHFRPGRADORA2A
SCHEMBL565298 0.78 ALDH1A1 (0.62) ALOX5ADORA2AALDH1A1TSHRALOX15
SCHEMBL30646075 0.78 ALDH1A1 (0.62) ALOX5ADORA2AALDH1A1TSHRALOX15
SCHEMBL25582792 0.78 ALOX5 (0.55) ALOX5DHFRPGRESR2PIK3CA
SCHEMBL30485727 0.78 IKBKB (0.41) ALDH1A1TSHRNPC1RAB9AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113264894-A Benzoxazole derivative and preparation method thereof 陕西维世诺新材料有限公司 2021-08-17 CN disclosed