Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 3/20 | 0.54 |
| ▸ | THRB | P10828 | 3/20 | 0.54 |
| ▸ | PPIA | P62937 | 4/20 | 0.52 |
| ▸ | DHODH | Q02127 | 2/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6448529 | 0.77 | THRA (0.56) | THRATHRBDHODHSMN1; SMN2ESR1 | |
| SCHEMBL28629532 | 0.77 | PTGER1 (0.59) | PPIAMEN1KMT2A | |
| SCHEMBL29108936 | 0.74 | THRA (0.66) | THRATHRBDHODHSMN1; SMN2PLAUR | |
| SCHEMBL6888341 | 0.73 | THRA (0.50) | THRATHRBDHODHSMN1; SMN2ESR1 | |
| SCHEMBL21408252 | 0.72 | LMNA (0.74) | THRATHRBDHODHSMN1; SMN2ESR1 | |
| SCHEMBL6279313 | 0.72 | THRA (0.52) | THRATHRBSMN1; SMN2 | |
| SCHEMBL6080336 | 0.72 | LMNA (0.49) | PPIASMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL6587878 | 0.72 | LMNA (0.49) | THRATHRBPPIASMN1; SMN2LMNA | |
| SCHEMBL6587872 | 0.72 | LMNA (0.49) | THRATHRBPPIASMN1; SMN2LMNA | |
| SCHEMBL5919087 | 0.72 | THRA (0.62) | THRATHRBDHODHSMN1; SMN2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109704982-B | Preparation method of eltrombopag intermediate 2-hydroxy-3- (m-carboxyphenyl) aniline | 上海天慈国际药业有限公司 | 2021-09-07 | — | — | CN | disclosed |