Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Chelerythrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 5/20 | 0.88 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.88 |
| ▸ | MAPT | P10636 | 8/20 | 0.88 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.88 |
| ▸ | HPGD | P15428 | 6/20 | 0.88 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.88 |
| ▸ | LMNA | P02545 | 6/20 | 0.88 |
| ▸ | BAD | Q92934 | 6/20 | 0.88 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.88 |
| ▸ | BCHE | P06276 | 5/20 | 0.88 |
| ▸ | RAC1 | P63000 | 4/20 | 0.88 |
| ▸ | POLB | P06746 | 3/20 | 0.88 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.88 |
| ▸ | GMNN | O75496 | 2/20 | 0.88 |
| ▸ | BLM | P54132 | 2/20 | 0.88 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.88 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.88 |
| ▸ | MEN1 | O00255 | 5/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chelerythrine SCHEMBL30207103 | 0.94 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2HPGDKMT2A | |
| Chelerythrine SCHEMBL195109 | 0.94 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2HPGDKMT2A | |
| Chelerythrine SCHEMBL30527167 | 0.93 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2HPGDKMT2A | |
| Chelerythrine SCHEMBL288915 | 0.93 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2HPGDKMT2A | |
| Chelerythrine SCHEMBL30527168 | 0.93 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2HPGDKMT2A | |
| Chelerythrine SCHEMBL29357531 | 0.93 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2HPGDKMT2A | |
| Chelerythrine SCHEMBL3319851 | 0.92 | ALDH1A1 (0.98) | ALDH1A1MAPTSMN1; SMN2HPGDKMT2A | |
| Chelerythrine SCHEMBL4016265 | 0.92 | ALDH1A1 (0.98) | ALDH1A1MAPTSMN1; SMN2HPGDKMT2A | |
| Chelerythrine SCHEMBL4980861 | 0.92 | ALDH1A1 (0.98) | ALDH1A1MAPTSMN1; SMN2HPGDKMT2A | |
| Chelerythrine SCHEMBL288916 | 0.92 | ALDH1A1 (0.98) | ALDH1A1MAPTSMN1; SMN2HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113207893-B | Degerming composition containing moroxydine hydrochloride and degerming agent | 一力制药股份有限公司 | 2022-01-11 | — | — | CN | disclosed |
| CN-113207893-A | Degerming composition containing moroxydine hydrochloride and degerming agent | 一力制药股份有限公司 | 2021-08-06 | — | — | CN | disclosed |