Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL744322 | 0.74 | ACHE (0.44) | KDM4EMAPTGAAALDH1A1CYP1A2 | |
| SCHEMBL2302753 | 0.72 | ACHE (0.38) | MAPTCYP3A4KMT2A | |
| SCHEMBL2828160 | 0.71 | GAA (0.32) | KDM4EMAPTGAAALDH1A1MAPK1 | |
| SCHEMBL28412483 | 0.68 | PKM (0.43) | KDM4EMAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL1715885 | 0.67 | GPR35 (0.41) | KDM4EALDH1A1USP2KMT2AHPGDS | |
| SCHEMBL2547123 | 0.67 | ALDH1A1 (0.50) | KDM4EMAPTLMNACYP2C9ALDH1A1 | |
| SCHEMBL31432665 | 0.67 | AR (0.44) | KDM4EMAPTLMNACYP2C9GAA | |
| SCHEMBL9084973 | 0.67 | ACHE (0.52) | KDM4EMAPTLMNACYP2C9GAA | |
| SCHEMBL24340392 | 0.66 | KDM4E (0.42) | KDM4EMAPTLMNACYP2C9GAA | |
| SCHEMBL5238964 | 0.66 | KDM4E (0.42) | KDM4EMAPTLMNACYP2C9GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2543390-A1 | Pharmaceutical composition | Kyowa Hakko Kirin Co., Ltd. (JP) | 2013-01-09 | — | — | EP | claimed |
| US-20100098690-A1 | PHARMACEUTICAL COMPOSITION | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-04-22 | — | — | US | claimed |
| EP-2133094-A1 | PHARMACEUTICAL COMPOSITION | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-12-16 | — | — | EP | claimed |
| US-20090042883-A1 | ANTITUMOR AGENT | KYOWA HAKKOKOGYO CO. (JP) | 2009-02-12 | — | — | US | claimed |
| EP-1852112-A1 | ANTI-TUMOR AGENT | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-11-07 | — | — | EP | claimed |
| US-20070032532-A1 | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-02-08 | — | — | US | claimed |
| EP-1642880-A1 | HSP90 FAMILY PROTEIN INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-04-05 | — | — | EP | claimed |
| EP-2543390-A1 | Pharmaceutical composition | Kyowa Hakko Kirin Co., Ltd. (JP) | 2013-01-09 | — | — | EP | disclosed |
| US-7767693-B2 | Hsp90 family protein inhibitors | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-08-03 | — | — | US | disclosed |
| US-20100104567-A1 | PHARMACEUTICAL COMPOSITION | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-04-29 | — | — | US | disclosed |
| US-20100098690-A1 | PHARMACEUTICAL COMPOSITION | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-04-22 | — | — | US | disclosed |
| EP-2133095-A1 | PHARMACEUTICAL COMPOSITION | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-12-16 | — | — | EP | disclosed |
| EP-2133094-A1 | PHARMACEUTICAL COMPOSITION | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-12-16 | — | — | EP | disclosed |
| US-20090247522-A1 | Hsp90 FAMILY PROTEIN INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-10-01 | — | — | US | disclosed |
| US-7538224-B2 | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-05-26 | — | — | US | disclosed |
| US-20090042883-A1 | ANTITUMOR AGENT | KYOWA HAKKOKOGYO CO. (JP) | 2009-02-12 | — | — | US | disclosed |
| EP-1852112-A1 | ANTI-TUMOR AGENT | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-11-07 | — | — | EP | disclosed |
| US-20070032532-A1 | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-02-08 | — | — | US | disclosed |
| EP-1642880-A1 | HSP90 FAMILY PROTEIN INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-04-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032532-A1 | Hsp90 family protein inhibitors | HSP90AB1, HSP90B1, HSP90AB2P | KDM4E 2968/4885MAPT 1791/4885LMNA 4283/4885 |
| US-20090247522-A1 | Hsp90 FAMILY PROTEIN INHIBITORS | HSP90AB1, HSP90B1, HSP90AB2P | KDM4E 2968/4885MAPT 1791/4885LMNA 4283/4885 |
| US-20090042883-A1 | ANTITUMOR AGENT | MCL1, HDAC7, TP53 | KDM4E 2024/4885MAPT 4878/4885LMNA 3169/4885 |
| US-20100104567-A1 | PHARMACEUTICAL COMPOSITION | FLT4, FLT3, FLT1 | KDM4E 907/4885MAPT 2970/4885LMNA 4253/4885 |
| US-20100098690-A1 | PHARMACEUTICAL COMPOSITION | HSP90B1, HSP90AB1, HSP90AB2P | KDM4E 3110/4885MAPT 1634/4885LMNA 4159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.