Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 4/20 | 0.41 |
| ▸ | TRPC1 | P48995 | 2/20 | 0.38 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.38 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.38 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 3/20 | 0.36 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | MST1R | Q04912 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2850524 | 0.87 | MAPT (0.43) | METTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL2855950 | 0.87 | POLB (0.41) | METMALT1MAPTLMNARAB9A | |
| SCHEMBL2859873 | 0.86 | KCNQ3 (0.46) | METTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL2853154 | 0.83 | MAPT (0.44) | METTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL2855275 | 0.83 | MAPT (0.45) | METTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL2856272 | 0.82 | MALT1 (0.53) | METTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL2856585 | 0.81 | CA1 (0.44) | MEN1KMT2A | |
| SCHEMBL2860990 | 0.81 | KEAP1 (0.43) | EPHX2MALT1MAPTMEN1LMNA | |
| SCHEMBL2852244 | 0.80 | MAPT (0.48) | METTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL2853065 | 0.79 | NR3C1 (0.46) | TRPC1TRPC3STIM1ORAI1STIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |