Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2862978 | 0.87 | MET (0.41) | SMN1; SMN2LMNAMALT1METAXL | |
| SCHEMBL2854269 | 0.83 | RAB9A (0.46) | POLBSMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL2850733 | 0.83 | KEAP1 (0.46) | KEAP1NFE2L2 | |
| SCHEMBL2855716 | 0.83 | KEAP1 (0.46) | POLBSMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL2850524 | 0.82 | MAPT (0.43) | SMN1; SMN2MALT1METAXLRAB9A | |
| SCHEMBL2850397 | 0.82 | MALT1 (0.57) | POLBSMN1; SMN2ALDH1A1MALT1KEAP1 | |
| SCHEMBL2850725 | 0.81 | MAPT (0.54) | POLBSMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL2854572 | 0.81 | RAB9A (0.44) | SMN1; SMN2RAB9AMAPTNPC1CCR1 | |
| SCHEMBL2855275 | 0.80 | MAPT (0.45) | METAXLRAB9AMAPTNPC1 | |
| SCHEMBL2857337 | 0.80 | KMT2A (0.43) | LMNAMALT1RAB9AMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |