Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 7/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 7/20 | 0.46 |
| ▸ | KCNQ5 | Q9NR82 | 5/20 | 0.46 |
| ▸ | KCNE1 | P15382 | 5/20 | 0.38 |
| ▸ | KCNQ1 | P51787 | 5/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 3/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.35 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.35 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.35 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.35 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2853154 | 0.86 | MAPT (0.44) | P2RX7METMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL2862978 | 0.86 | MET (0.41) | METMALT1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL2852244 | 0.81 | MAPT (0.48) | METMAPTSMN1; SMN2NPSR1TRPC1 | |
| SCHEMBL2860990 | 0.79 | KEAP1 (0.43) | MALT1MAPT | |
| SCHEMBL2856585 | 0.79 | CA1 (0.44) | — | |
| SCHEMBL2848317 | 0.78 | MAPT (0.46) | METMAPTSMN1; SMN2NPSR1TRPC1 | |
| SCHEMBL2854572 | 0.78 | RAB9A (0.44) | P2RX7MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL2858182 | 0.78 | P2RX7 (0.44) | P2RX7MAPTNPSR1 | |
| SCHEMBL2850258 | 0.78 | MAPT (0.51) | MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL2854500 | 0.78 | MET (0.34) | METMALT1MAPTNPSR1TRPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |