SCHEMBL28630419

SCHEMBL28630419

Clc1ccc(C#Cc2cccc(Cl)c2)cc1

nearest known ligand 0.60

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 2/20 0.58
GRM5 P41594 8/20 0.53
CYP2C9 P11712 1/20 0.46
PTGDR2 Q9Y5Y4 1/20 0.46
HAO1 Q9UJM8 2/20 0.43
MAOB P27338 1/20 0.42
APP P05067 1/20 0.42
CYP2D6 P10635 1/20 0.41
PTPRC P08575 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30081497 1.00 KCNH2 (0.58) KCNH2GRM5CYP2C9PTGDR2HAO1
Ammonia Solution, Strong SCHEMBL5555414 0.98 KCNH2 (0.56) KCNH2GRM5CYP2C9PTGDR2HAO1
SCHEMBL4562631 0.91 KCNH2 (0.67) KCNH2GRM5CYP2C9PTGDR2HAO1
SCHEMBL30707869 0.91 KCNH2 (0.67) KCNH2GRM5CYP2C9PTGDR2HAO1
SCHEMBL717449 0.88 KCNH2 (0.60) KCNH2GRM5CYP2C9PTGDR2HAO1
Charcoal, Activated SCHEMBL31286308 0.88 KCNH2 (0.64) KCNH2GRM5CYP2C9PTGDR2HAO1
SCHEMBL701787 0.81 KCNH2 (0.53) KCNH2GRM5HAO1APP
SCHEMBL717633 0.80 APP (0.67) KCNH2GRM5CYP2C9PTGDR2APP
SCHEMBL20015814 0.80 LMNA (0.57) KCNH2GRM5PTGDR2MAOBAPP
SCHEMBL719360 0.80 LMNA (0.57) KCNH2GRM5PTGDR2MAOBAPP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113443952-B Method for selectively synthesizing cis-olefin and trans-olefin by catalyzing alkyne semi-reduction through iridium with hydrogen supplied by water 南通大学 2022-11-04 CN disclosed
CN-113443952-A Method for selectively synthesizing cis-olefin and trans-olefin by catalyzing alkyne semi-reduction through iridium with hydrogen supplied by water 南通大学 2021-09-28 CN disclosed