Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2850427 | 0.92 | SMN1; SMN2 (0.60) | TP53THRBALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL2854686 | 0.91 | SMN1; SMN2 (0.52) | TP53ALDH1A1SMN1; SMN2TSHRHPGD | |
| SCHEMBL2856388 | 0.91 | TRPV1 (0.51) | TP53THRBALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL2848518 | 0.90 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2TSHRKDM4EMAPT | |
| SCHEMBL2857766 | 0.88 | ALDH1A1 (0.56) | TP53THRBALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL2862835 | 0.87 | SMN1; SMN2 (0.52) | ALDH1A1SMN1; SMN2NPSR1MAPTHPGD | |
| SCHEMBL2856625 | 0.84 | TSHR (0.48) | SMN1; SMN2TSHRNPSR1 | |
| SCHEMBL2860466 | 0.84 | RCE1 (0.47) | TP53THRBALDH1A1MAPTRXFP1 | |
| SCHEMBL2850129 | 0.83 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2KDM4EMAPTHPGD | |
| SCHEMBL2848661 | 0.83 | ABCB1 (0.48) | TP53ALDH1A1SMN1; SMN2MAPTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |