Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 4/20 | 0.45 |
| ▸ | MAP4K3 | Q8IVH8 | 6/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | GRK2 | P25098 | 1/20 | 0.33 |
| ▸ | GRK5 | P34947 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28927885 | 0.91 | MAP4K3 (0.43) | KDM1AMAP4K3MAP4K1ALKMET | |
| SCHEMBL28927868 | 0.86 | GPR119 (0.38) | KDM1A | |
| SCHEMBL28634046 | 0.84 | MAP4K3 (0.59) | MAP4K3ALKMETACVRL1ACVR1 | |
| SCHEMBL28927875 | 0.78 | GPR119 (0.39) | KDM1A | |
| SCHEMBL28638645 | 0.76 | MAP4K3 (0.39) | KDM1AMAP4K3MAP4K1JAK2 | |
| SCHEMBL29929924 | 0.73 | MAP3K7 (0.47) | MAP4K3MAP4K1 | |
| SCHEMBL28927864 | 0.73 | PIM1 (0.43) | MAP4K1 | |
| SCHEMBL28927866 | 0.73 | MAP4K1 (0.46) | MAP4K1ACVRL1ACVR1TYK2 | |
| SCHEMBL28636439 | 0.72 | MAP3K7 (0.51) | MAP4K3 | |
| SCHEMBL28633555 | 0.70 | MAP4K1 (0.42) | KDM1AMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115244050-B | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-115244050-A | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2022-10-25 | — | — | CN | disclosed |