SCHEMBL286351

SCHEMBL286351

O=Cc1ccc([N+](=O)[O-])cn1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC2A1 P11166 1/20 0.64
MAPT P10636 5/20 0.46
ADRA2A P08913 2/20 0.46
ADRA2B P18089 2/20 0.46
ADRA2C P18825 2/20 0.46
ALDH1A1 P00352 4/20 0.45
LMNA P02545 3/20 0.45
KMT2A Q03164 3/20 0.45
MEN1 O00255 2/20 0.45
CYP1A2 P05177 2/20 0.45
ALOX12 P18054 2/20 0.45
GAA P10253 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
KDM4E B2RXH2 1/20 0.44
AGTR1 P30556 1/20 0.44
HPGD P15428 2/20 0.42
HSPB1 P04792 1/20 0.42
CYP2C9 P11712 1/20 0.42
HSP90AA1 P07900 1/20 0.42
CXCR5 P32302 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29953371 1.00 SLC2A1 (0.64) SLC2A1MAPTADRA2AADRA2BADRA2C
SCHEMBL1546237 0.82 SLC2A1 (0.62) SLC2A1MAPTADRA2AADRA2BADRA2C
SCHEMBL27875451 0.82 SLC2A1 (0.62) SLC2A1MAPTADRA2AADRA2BADRA2C
SCHEMBL9000418 0.79 SLC2A1 (0.58) SLC2A1MAPTADRA2AADRA2BADRA2C
SCHEMBL25042631 0.78 SLC2A1 (1.00) SLC2A1MAPTADRA2AADRA2BADRA2C
SCHEMBL30275251 0.78 SLC2A1 (1.00) SLC2A1MAPTADRA2AADRA2BADRA2C
SCHEMBL30275111 0.78 SLC2A1 (1.00) SLC2A1MAPTADRA2AADRA2BADRA2C
SCHEMBL14988861 0.77 MAPT (0.56) SLC2A1MAPTALDH1A1LMNAKMT2A
SCHEMBL14988862 0.77 MAPT (0.56) SLC2A1MAPTALDH1A1LMNAKMT2A
SCHEMBL20337186 0.77 SLC2A1 (0.59) SLC2A1MAPTADRA2AADRA2BADRA2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 213 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12606544-B2 JAK1 selective kinase inhibitor DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) 2026-04-21 US disclosed
EP-3956322-B1 JAK1 SELECTIVE KINASE INHIBITOR DIZAL JIANGSU PHARMACEUTICAL CO LTD (CN) 2025-05-14 EP disclosed
WO-2025059562-A1 SUBSTITUTED AMINOPYRIDINE COMPOUNDS AND METHODS OF TREATING DISEASE USING SAME ATAVISTIK BIO, INC. (US) 2025-03-20 WO disclosed
US-20250026742-A1 COMPOUND AS ATR KINASE INHIBITOR SUZHOU ARK BIOPHARMACEUTICAL CO., LTD. (CN) 2025-01-23 US disclosed
US-12173018-B2 Penicillin-binding protein inhibitors VenatoRx Pharmaceuticals, Inc. (US) 2024-12-24 US disclosed
CN-113631535-B Heteroaryl and bisheteroaryl derivatives for the treatment of iron death-related disorders 协同医药发展有限公司 2024-04-12 CN disclosed
EP-3583105-B1 PYRROLO [1,2-B]PYRIDAZINE DERIVATIVES GILEAD SCIENCES INC (US) 2024-02-07 EP disclosed
CN-113710664-B JAK1 selective kinase inhibitors 迪哲(江苏)医药股份有限公司 2024-01-26 CN disclosed
CN-114096532-B Heterocyclic compounds which inhibit tyrosine kinase 2 activity 广州诺诚健华医药科技有限公司 2023-12-01 CN disclosed
US-11780823-B2 Indazole-3-carboxamides and their use as Wnt/β-catenin signaling pathway inhibitors BIOSPLICE THERAPEUTICS, INC. (US) 2023-10-10 US disclosed
WO-2002008201-A2 BETA-AMINO ACID DERIVATIVES-INHIBITORS OF LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARMACEUTICALS, INC. (US) 2002-01-31 WO disclosed
WO-2002004443-A2 HETEROCYCLE CARBOXAMIDES AS ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 2002-01-17 WO disclosed
CN-1327443-A Substituted anilide compounds ARVENTIS PHARMACEUTICALS CO LT (GB) 2001-12-19 CN disclosed
EP-1027328-A1 SUBSTITUTED ANILIDES Aventis Pharma Limited (GB) 2000-08-16 EP disclosed
WO-1999023063-A1 SUBSTITUTED ANILIDES AVENTIS PHARMA LIMITED (GB) 1999-05-14 WO disclosed
US-5721259-A Method of using 2-formylpyridine thiosemicarbazone compounds YALE UNIVERSITY (US) 1998-02-24 US disclosed
EP-0570294-B1 2-Formylpyridine thiosemicarbazone derivatives, their preparation and their use as antitumor agents UNIV YALE (US) 1997-07-30 EP disclosed
US-5281715-A 2-formylpyridine thiosemicarbazone compounds YALE UNIVERSITY (US) 1994-01-25 US disclosed
EP-0570294-A1 2-Formylpyridine thiosemicarbazone derivatives, their preparation and their use as antitumor agents YALE UNIVERSITY (US) 1993-11-18 EP disclosed
US-5207952-A Polyesters with pendant side chains UNIVERSITY OF SOUTHERN MISSISSIPPI (US) 1993-05-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250026742-A1 COMPOUND AS ATR KINASE INHIBITOR ATR, CHEK2, CHEK1 SLC2A1 4689/4885MAPT 1987/4885ADRA2A 3769/4885
US-12606544-B2 JAK1 selective kinase inhibitor JAK1, JAK2, JAK3 SLC2A1 4356/4885MAPT 4828/4885ADRA2A 1523/4885
US-12173018-B2 Penicillin-binding protein inhibitors PEPD, BPGM, EBPL SLC2A1 2540/4885MAPT 3146/4885ADRA2A 4763/4885
US-11780823-B2 Indazole-3-carboxamides and their use as Wnt/β-catenin signaling pathway inhibitors WNT1, WNT3, WNT3A SLC2A1 3949/4885MAPT 569/4885ADRA2A 2883/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.