Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of D-Glutamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 14/20 | 0.40 |
| ▸ | CA2 | P00918 | 14/20 | 0.40 |
| ▸ | MMP1 | P03956 | 6/20 | 0.39 |
| ▸ | MMP2 | P08253 | 6/20 | 0.39 |
| ▸ | MMP9 | P14780 | 6/20 | 0.39 |
| ▸ | MMP8 | P22894 | 6/20 | 0.39 |
| ▸ | MMP13 | P45452 | 6/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.30 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.30 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL28482838 | 0.98 | CA2 (0.40) | CA1CA2MMP1MMP2MMP9 | |
| D-Glutamate SCHEMBL28475206 | 0.90 | CA1 (0.40) | CA1CA2MMP1MMP2MMP9 | |
| D-Glutamate SCHEMBL29412572 | 0.83 | CA2 (0.36) | CA1CA2MMP1MMP2MMP9 | |
| D-Glutamate SCHEMBL29206239 | 0.79 | — | — | |
| SCHEMBL9157457 | 0.77 | CA1 (0.52) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL9069154 | 0.77 | CA1 (0.52) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL4784342 | 0.77 | CA1 (0.52) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL9069199 | 0.77 | CA1 (0.52) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL9068698 | 0.77 | CA1 (0.52) | CA1CA2MMP1MMP2MMP9 | |
| Alcohol SCHEMBL11154176 | 0.76 | CA1 (0.52) | CA1CA2MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108975646-B | Oil sludge demulsifier and preparation method and application thereof | 浙江奇彩环境科技股份有限公司 | 2021-10-22 | — | — | CN | disclosed |