SCHEMBL28644499

SCHEMBL28644499

COc1ccc(N2CN(c3ccccc3)N(c3ccccc3)C2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.49
PKM P14618 1/20 0.49
HTR3E A5X5Y0 1/20 0.49
HTR3B O95264 1/20 0.49
ADRB1 P08588 1/20 0.49
HTR3A P46098 1/20 0.49
HTR3D Q70Z44 1/20 0.49
HTR3C Q8WXA8 1/20 0.49
SIGMAR1 Q99720 1/20 0.49
MAPT P10636 5/20 0.47
RAB9A P51151 1/20 0.47
KMT2A Q03164 1/20 0.47
CA4 P22748 1/20 0.46
TDP1 Q9NUW8 2/20 0.46
MAPK1 P28482 2/20 0.46
LTA4H P09960 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
HTT P42858 1/20 0.44
DRD2 P14416 1/20 0.44
USP2 O75604 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30277734 0.83 ALDH1A1 (0.58) ALDH1A1PKMHTR3EHTR3BADRB1
SCHEMBL6153220 0.82 ALDH1A1 (0.66) ALDH1A1PKMHTR3EHTR3BADRB1
SCHEMBL23918685 0.82 CA1 (0.55) HTR3EHTR3BADRB1HTR3AHTR3D
SCHEMBL11504114 0.82 HTR3E (0.61) HTR3EHTR3BADRB1HTR3AHTR3D
SCHEMBL28644066 0.82 LMNA (0.46) ALDH1A1HTR3EHTR3BADRB1HTR3A
SCHEMBL30461173 0.79 MAPT (0.45) PKMADRB1MAPTRAB9AKMT2A
SCHEMBL28652659 0.79 MAPT (0.45) PKMADRB1MAPTRAB9AKMT2A
SCHEMBL4793606 0.76 HTR3E (0.59) ALDH1A1HTR3EHTR3BADRB1HTR3A
SCHEMBL28661355 0.75 DRD4 (0.49) ALDH1A1HTR3EHTR3BADRB1HTR3A
SCHEMBL30461171 0.75 DRD4 (0.49) ALDH1A1HTR3EHTR3BADRB1HTR3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113480485-B 1,2, 4-triaryl-1, 2, 4-triazoles compound and synthetic method thereof 甘肃农业大学 2023-04-07 CN disclosed
CN-113480485-A 1,2, 4-triaryl-1, 2, 4-triazoles compound and synthetic method thereof 甘肃农业大学 2021-10-08 CN disclosed