Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.39 |
| ▸ | CES1 | P23141 | 3/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.38 |
| ▸ | PPARG | P37231 | 7/20 | 0.38 |
| ▸ | PPARD | Q03181 | 7/20 | 0.38 |
| ▸ | PPARA | Q07869 | 7/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 5/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TLR2 | O60603 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | FABP4 | P15090 | 2/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7505879 | 1.00 | CES2 (0.39) | CES2CES1GPR84PPARGPPARD | |
| SCHEMBL20875834 | 1.00 | CES2 (0.39) | CES2CES1GPR84PPARGPPARD | |
| SCHEMBL9729344 | 1.00 | CES2 (0.39) | CES2CES1GPR84PPARGPPARD | |
| SCHEMBL11350585 | 0.83 | — | — | |
| SCHEMBL8730946 | 0.81 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL20875840 | 0.81 | SPHK2 (0.40) | CES2CES1GPR84PPARGPPARD | |
| SCHEMBL11342107 | 0.80 | — | — | |
| SCHEMBL10898312 | 0.79 | LSS (0.40) | PPARGALDH1A1MEN1ALOX15KMT2A | |
| SCHEMBL16485010 | 0.78 | TSHR (0.43) | TSHRMEN1KMT2A | |
| SCHEMBL10375151 | 0.77 | CES2 (0.46) | CES2CES1GPR84PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389569-B2 | Polyspirane compounds, application thereof in the treatment of malaria or toxoplasmosis and method for preparing same | UNIVERSITE JOSEPH FOURIER (FR) | 2013-03-05 | — | — | US | disclosed |
| EP-2195323-B1 | Polyspirane compounds, use thereof in the treatment of malaria or toxoplasmosis and method for their preparation | UNIV JOSEPH FOURIER (FR) | 2011-12-28 | — | — | EP | disclosed |
| US-20100298422-A1 | NOVEL POLYSPIRANE COMPOUNDS, APPLICATION THEREOF IN THE TREATMENT OF MALARIA OR TOXOPLASMOSIS AND METHOD FOR PREPARING SAME | UNIVERSITE JOSEPH FOURIER (FR) | 2010-11-25 | — | — | US | disclosed |
| EP-2195323-A2 | NOVEL POLYSPIRANE COMPOUNDS, APPLICATION THEREOF IN THE TREATMENT OF MALARIA OR TOXOPLASMOSIS AND METHOD FOR PREPARING SAME | Université Joseph Fourier (FR) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009077677-A2 | NOVEL POLYSPIRANE COMPOUNDS, APPLICATION THEREOF IN THE TREATMENT OF MALARIA OR TOXOPLASMOSIS AND METHOD FOR PREPARING SAME | UNIVERSITE JOSEPH FOURIER (FR) | 2009-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298422-A1 | NOVEL POLYSPIRANE COMPOUNDS, APPLICATION THEREOF IN THE TREATMENT OF MALARIA OR TOXOPLASMOSIS AND METHOD FOR PREPARING SAME | FLOT1, PHOSPHO1, GPAA1 | CES2 2537/4885CES1 2249/4885GPR84 405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.