Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 4/20 | 0.34 |
| ▸ | RXRA | P19793 | 3/20 | 0.34 |
| ▸ | RXRG | P48443 | 3/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.32 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28663602 | 0.80 | SIRT2 (0.44) | LOXL2ALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL19259915 | 0.80 | LOXL2 (0.38) | LOXL2ALOX15TSHRHSD17B10NPC1 | |
| SCHEMBL28644238 | 0.79 | LOXL2 (0.41) | LOXL2ALDH1A1SMN1; SMN2NTRK1LOXL3 | |
| SCHEMBL28643885 | 0.78 | LOXL3 (0.36) | LOXL2ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28645865 | 0.76 | LOXL2 (0.40) | LOXL2TSHRSMN1; SMN2NTRK1LOXL3 | |
| SCHEMBL19274589 | 0.76 | PDPK1 (0.41) | LOXL2NPC1RAB9ASMN1; SMN2NTRK1 | |
| SCHEMBL29971063 | 0.76 | PDPK1 (0.41) | LOXL2NPC1RAB9ASMN1; SMN2NTRK1 | |
| SCHEMBL28657391 | 0.76 | LOXL2 (0.43) | LOXL2ALDH1A1TSHRHSD17B10RAB9A | |
| SCHEMBL28651596 | 0.75 | ALDH1A1 (0.42) | LOXL2ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL28643913 | 0.75 | LOXL2 (0.38) | LOXL2NTRK1LOXL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109311839-B | Methylamine derivatives as lysyl oxidase inhibitors for the treatment of cancer | 癌症研究协会皇家癌症医院 | 2021-11-02 | — | — | CN | disclosed |