Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC8 | Q09428 | 1/20 | 0.50 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ELANE | P08246 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18924216 | 0.83 | TSHR (0.56) | ABCC8KCNJ11TSHRRAB9ASMN1; SMN2 | |
| SCHEMBL2862045 | 0.76 | ABCC8 (0.50) | ABCC8KCNJ11TSHRRAB9ASMN1; SMN2 | |
| SCHEMBL22005508 | 0.74 | ILK (0.51) | TSHRRAB9ASMN1; SMN2TDP1KMT2A | |
| SCHEMBL19923805 | 0.72 | TDP1 (0.47) | TSHRRAB9ASMN1; SMN2TDP1KMT2A | |
| SCHEMBL18869086 | 0.71 | TDP1 (0.50) | TSHRRAB9ASMN1; SMN2TDP1KMT2A | |
| SCHEMBL22005553 | 0.71 | RAB9A (0.53) | TSHRRAB9ASMN1; SMN2TDP1KMT2A | |
| SCHEMBL20154221 | 0.71 | RAB9A (0.56) | TSHRRAB9ASMN1; SMN2TDP1KMT2A | |
| SCHEMBL5717545 | 0.71 | ABCC8 (0.41) | ABCC8KCNJ11TSHRRAB9ATDP1 | |
| SCHEMBL20154271 | 0.71 | RAB9A (0.59) | TSHRRAB9ASMN1; SMN2TDP1KMT2A | |
| SCHEMBL20154222 | 0.70 | RAB9A (0.55) | TSHRRAB9ASMN1; SMN2TDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1852428-B1 | 4-CYCLOPROPYL-1,2,3-THIADIAZOLE COMPOUND, AGROHORTICULTURAL PLANT DISEASE CONTROLLING AGENT AND METHOD OF USING THE SAME | NIHON NOHYAKU CO LTD (JP) | 2012-05-16 | — | — | EP | disclosed |
| US-7786040-B2 | 4-cyclopropyl-1,2,3,-thiadiazole compound, agrohorticultural plant disease controlling agent and method of using the same | NIHON NOHYAKU CO., LTD. (JP) | 2010-08-31 | — | — | US | disclosed |
| US-20080200457-A1 | 4-Cyclopropyl-1,2,3,-Thiadiazole Compound, Agrohorticultural Plant Disease Controlling Agent And Method Of Using The Same | NIHON NOHYAKU CO., LTD. (JP) | 2008-08-21 | — | — | US | disclosed |
| EP-1852428-A1 | 4-CYCLOPROPYL-1,2,3-THIADIAZOLE COMPOUND, AGROHORTICULTURAL PLANT DISEASE CONTROLLING AGENT AND METHOD OF USING THE SAME | Nihon Nohyaku Co., Ltd. (JP) | 2007-11-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200457-A1 | 4-Cyclopropyl-1,2,3,-Thiadiazole Compound, Agrohorticultural Plant Disease Controlling Agent And Method Of Using The Same | CBR3, CBR1, OSR1 | ABCC8 1005/4885KCNJ11 1207/4885TSHR 653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.