Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.46 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11535110 | 0.86 | MAPT (0.64) | SMN1; SMN2MAPTLMNAPOLBKMT2A | |
| SCHEMBL2867253 | 0.83 | ABCC8 (0.50) | TSHRRAB9ASMN1; SMN2MAPTATM | |
| SCHEMBL10335263 | 0.81 | HTT (0.49) | RAB9ASMN1; SMN2MAPTLMNAPOLB | |
| SCHEMBL20154221 | 0.79 | RAB9A (0.56) | TSHRRAB9ASMN1; SMN2MAPTATM | |
| SCHEMBL22005508 | 0.79 | ILK (0.51) | TSHRRAB9ASMN1; SMN2MAPTATM | |
| SCHEMBL20154222 | 0.78 | RAB9A (0.55) | TSHRRAB9ASMN1; SMN2MAPTLMNA | |
| SCHEMBL2862045 | 0.78 | ABCC8 (0.50) | TSHRRAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL2211256 | 0.77 | MAPT (0.54) | TSHRMAPTLMNAPOLBKMT2A | |
| SCHEMBL22005553 | 0.77 | RAB9A (0.53) | TSHRRAB9ASMN1; SMN2MAPTATM | |
| SCHEMBL21550516 | 0.77 | RAB9A (0.71) | TSHRRAB9ASMN1; SMN2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9688683-B2 | Substituted condensed pyrimidine compounds | Grünenthal GmbH (DE) | 2017-06-27 | — | — | US | disclosed |
| US-9670189-B2 | Substituted condensed pyrimidine compounds | Grünenthal GmbH (DE) | 2017-06-06 | — | — | US | disclosed |