Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL194872 | 0.88 | TSHR (0.38) | TSHR | |
| SCHEMBL2761366 | 0.88 | TSHR (0.38) | TSHR | |
| SCHEMBL2915774 | 0.87 | TSHR (0.47) | TSHRLMNA | |
| SCHEMBL7338345 | 0.86 | TSHR (0.36) | TSHR | |
| SCHEMBL11626081 | 0.86 | TSHR (0.36) | TSHR | |
| SCHEMBL395804 | 0.86 | TSHR (0.36) | TSHR | |
| SCHEMBL6944961 | 0.82 | KDM4E (0.30) | LMNA | |
| SCHEMBL6946347 | 0.78 | — | — | |
| SCHEMBL13593718 | 0.78 | ESR2 (0.34) | TSHR | |
| SCHEMBL13496495 | 0.75 | TSHR (0.36) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2880008-A1 | PROCESS FOR PREPARING SPIRO[2.5]OCTANE-5,7-DIONE | Boehringer Ingelheim International GmbH (DE) | 2015-06-10 | — | — | EP | claimed |
| US-20140336405-A1 | Process for preparing spiro[2.5]octane-5,7-dione | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-11-13 | — | — | US | claimed |
| US-20140039203-A1 | Process for preparing spiro[2.5]octane-5,7-dione | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-02-06 | — | — | US | claimed |
| WO-2014020038-A1 | PROCESS FOR PREPARING SPIRO[2.5]OCTANE-5,7-DIONE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-02-06 | — | — | WO | claimed |
| EP-4719369-A2 | INHIBITORS OF FATTY ACID BINDING PROTEINS (FABPS), METHODS OF USE AND METHODS OF MAKING | Celloram, Inc. (US) | 2026-04-08 | — | — | EP | disclosed |
| WO-2025080689-A1 | LIPID PRODRUGS OF BROMOLYSERGIDE AND USES THEREOF | SEAPORT THERAPEUTICS, INC. (US) | 2025-04-17 | — | — | WO | disclosed |
| WO-2024254161-A2 | INHIBITORS OF FATTY ACID BINDING PROTEINS (FABPS), METHODS OF USE AND METHODS OF MAKING | CELLORAM INC. (US) | 2024-12-12 | — | — | WO | disclosed |
| US-10570116-B2 | 1,4-dicarbonyl-piperidyl derivatives | MERCK PATENT GMBH (DE) | 2020-02-25 | — | — | US | disclosed |
| EP-3371166-B1 | 1,4-DICARBONYL-PIPERIDYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-11-20 | — | — | EP | disclosed |
| EP-2880008-B1 | PROCESS FOR PREPARING SPIRO[2.5]OCTANE-5,7-DIONE | BOEHRINGER INGELHEIM INT (DE) | 2019-05-29 | — | — | EP | disclosed |
| EP-2880008-B1 | PROCESS FOR PREPARING SPIRO[2.5]OCTANE-5,7-DIONE | BOEHRINGER INGELHEIM INT (DE) | 2019-05-29 | — | — | EP | disclosed |
| US-20190092751-A1 | 1,4-DICARBONYL-PIPERIDYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-03-28 | — | — | US | disclosed |
| US-20140039203-A1 | Process for preparing spiro[2.5]octane-5,7-dione | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-02-06 | — | — | US | disclosed |
| WO-2014020038-A1 | PROCESS FOR PREPARING SPIRO[2.5]OCTANE-5,7-DIONE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-02-06 | — | — | WO | disclosed |
| WO-2013116682-A1 | MACROCYCLIC COMPOUNDS FOR MODULATING IL-17 | ENSEMBLE THERAPEUTICS CORPORATION (US) | 2013-08-08 | — | — | WO | disclosed |
| US-20120122942-A1 | 5-OXO-ETE RECEPTOR ANTAGONIST COMPOUNDS | FLORIDA INSTITUTE OF TECHNOLOGY | 2012-05-17 | — | — | US | disclosed |
| EP-2427430-A1 | 5-OXO-ETE RECEPTOR ANTAGONIST COMPOUNDS | The Royal Institution for the Advancement of Learning / McGill University (CA) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010127452-A1 | 5-OXO-ETE RECEPTOR ANTAGONIST COMPOUNDS | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2010-11-11 | — | — | WO | disclosed |
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5124336-A | Cardiovascular disorders | LABORATOIRES UPSA (FR) | 1992-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140039203-A1 | Process for preparing spiro[2.5]octane-5,7-dione | SQLE, DHPS, CYP3A5 | TSHR 2945/4885LMNA 928/4885CYP2C9 128/4885 |
| US-10570116-B2 | 1,4-dicarbonyl-piperidyl derivatives | TNKS, TANK, TBKBP1 | TSHR 3489/4885LMNA 2999/4885CYP2C9 3606/4885 |
| US-20120122942-A1 | 5-OXO-ETE RECEPTOR ANTAGONIST COMPOUNDS | OXER1, PTGIR, EDNRA | TSHR 739/4885LMNA 3814/4885CYP2C9 696/4885 |
| US-20190092751-A1 | 1,4-DICARBONYL-PIPERIDYL DERIVATIVES | TNKS, TANK, TBKBP1 | TSHR 3489/4885LMNA 2999/4885CYP2C9 3606/4885 |
| US-20140336405-A1 | Process for preparing spiro[2.5]octane-5,7-dione | SQLE, DHPS, CYP3A5 | TSHR 2945/4885LMNA 928/4885CYP2C9 128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.