SCHEMBL28697207

SCHEMBL28697207

Cc1cccc(F)c1NC(=O)CN

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.51
MEN1 O00255 4/20 0.50
KMT2A Q03164 4/20 0.50
CYP2C9 P11712 3/20 0.50
CYP1A2 P05177 2/20 0.50
NFKB1 P19838 1/20 0.50
CYP2C19 P33261 1/20 0.50
MAPT P10636 3/20 0.47
SCN3A Q9NY46 3/20 0.47
SCN1A P35498 2/20 0.47
SCN2A Q99250 2/20 0.47
CYP3A4 P08684 2/20 0.47
HDAC3 O15379 1/20 0.47
HDAC4 P56524 1/20 0.47
HDAC1 Q13547 1/20 0.47
HDAC7 Q8WUI4 1/20 0.47
HDAC2 Q92769 1/20 0.47
HDAC10 Q969S8 1/20 0.47
HDAC11 Q96DB2 1/20 0.47
HDAC8 Q9BY41 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15145816 0.88 KMT2A (0.53) LMNAMEN1KMT2ACYP2C9CYP1A2
Glycinexylidide SCHEMBL4107220 0.88 LMNA (0.65) LMNAMEN1KMT2ACYP2C9CYP1A2
SCHEMBL18296970 0.83 SMN1; SMN2 (0.53) LMNAMEN1KMT2ACYP2C9CYP1A2
SCHEMBL22407655 0.83 MAPT (0.51) LMNAMEN1KMT2ACYP2C9CYP1A2
SCHEMBL26752182 0.81 NLRP3 (0.48) LMNAMEN1KMT2ACYP2C9CYP1A2
SCHEMBL18955464 0.80 ALDH1A1 (0.55) MEN1KMT2ACYP2C9CYP1A2NFKB1
SCHEMBL11414687 0.80 POLB (0.61) LMNAMEN1KMT2ACYP2C9CYP1A2
SCHEMBL6923968 0.79 HDAC3 (0.67) LMNAMEN1KMT2ACYP2C9CYP1A2
SCHEMBL3598057 0.79 ALDH1A1 (0.50) MEN1KMT2ACYP2C9CYP1A2NFKB1
SCHEMBL20194482 0.79 ALDH1A1 (0.53) MEN1KMT2ACYP2C9CYP1A2NFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119874561-A Charged ion channel blockers and methods of use thereof 诺西恩医疗公司 2025-04-25 CN disclosed
CN-113950471-B Charged ion channel blockers and methods of use thereof 诺西恩医疗公司 2025-01-14 CN disclosed
CN-113950471-A Charged ion channel blockers and methods of use thereof 诺西恩医疗公司 2022-01-18 CN disclosed