Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.45 |
| ▸ | SCN1A | P35498 | 2/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21186773 | 0.83 | ALDH1A1 (0.51) | NLRP3MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL28697207 | 0.81 | LMNA (0.51) | NLRP3MEN1KMT2ACYP2C9CYP1A2 | |
| SCHEMBL22407655 | 0.81 | MAPT (0.51) | NLRP3MEN1KMT2ACYP2C9CYP1A2 | |
| SCHEMBL18296970 | 0.81 | SMN1; SMN2 (0.53) | MEN1KMT2ACYP2C9CYP1A2NFKB1 | |
| SCHEMBL19781758 | 0.80 | NLRP3 (0.53) | NLRP3MEN1KMT2ACYP2C9CYP1A2 | |
| SCHEMBL26752202 | 0.79 | KMT2A (0.46) | NLRP3MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL18955464 | 0.78 | ALDH1A1 (0.55) | NLRP3MEN1KMT2ACYP2C9CYP1A2 | |
| SCHEMBL2032930 | 0.78 | ALDH1A1 (0.59) | NLRP3MEN1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL3598057 | 0.76 | ALDH1A1 (0.50) | NLRP3MEN1KMT2ACYP2C9CYP1A2 | |
| SCHEMBL20194482 | 0.76 | ALDH1A1 (0.53) | NLRP3MEN1KMT2ACYP2C9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230357272-A1 | OCTAHYDROPYRAZINODIAZANAPHTHYRIDINE DIONE COMPOUNDS | MEDSHINE DISCOVERY INC. (CN) | 2023-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230357272-A1 | OCTAHYDROPYRAZINODIAZANAPHTHYRIDINE DIONE COMPOUNDS | QDPR, SLCO1B3, SLC10A6 | NLRP3 3670/4885MEN1 3142/4885KMT2A 4097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.