Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 18/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | HTR2C | P28335 | 3/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28719535 | 0.84 | PKM (0.34) | HTR6CYP3A4PKM | |
| SCHEMBL28715521 | 0.82 | PKM (0.42) | HTR6DRD2HTR2BHTR1AHTR7 | |
| SCHEMBL28716232 | 0.82 | HTR6 (0.51) | HTR6CYP3A4 | |
| SCHEMBL28719532 | 0.82 | HTR6 (0.47) | HTR6PKMPKLR | |
| SCHEMBL28936720 | 0.80 | CTSG (0.46) | HTR6 | |
| SCHEMBL28715560 | 0.79 | HTR6 (0.49) | HTR6DRD2HTR2CHTR1AHTR2A | |
| SCHEMBL28715559 | 0.79 | PKM (0.45) | HTR6PKMPKLR | |
| SCHEMBL28715570 | 0.77 | GRM4 (0.37) | HTR6PKM | |
| SCHEMBL28719536 | 0.77 | HTR6 (0.43) | HTR6PKMPKLR | |
| SCHEMBL28706337 | 0.77 | PKM (0.44) | HTR6HTR1ADRD3PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114105962-A | Compound containing sulfonamide structure, preparation method and application thereof, and pharmaceutical composition and application thereof | 南京烁慧医药科技有限公司 | 2022-03-01 | — | — | CN | disclosed |