Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.36 |
| ▸ | CTSB | P07858 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | LIPE | Q05469 | 6/20 | 0.35 |
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL477283 | 0.87 | LIPE (0.42) | USP2SMN1; SMN2CTSLCTSBL3MBTL1 | |
| SCHEMBL694641 | 0.85 | LIPE (0.44) | CTSLCTSBL3MBTL1LIPECTSK | |
| SCHEMBL7365934 | 0.85 | LIPE (0.44) | CTSLCTSBL3MBTL1LIPECTSK | |
| SCHEMBL1576452 | 0.83 | CTSK (0.40) | USP2SMN1; SMN2CTSLCTSBL3MBTL1 | |
| SCHEMBL25724325 | 0.82 | SMN1; SMN2 (0.53) | USP2SMN1; SMN2CTSLCTSBCTSD | |
| SCHEMBL1430236 | 0.73 | LIPE (0.36) | CTSLCTSBL3MBTL1CTSDCTSS | |
| SCHEMBL7151133 | 0.73 | GNAI3 (0.38) | CTSLCTSBL3MBTL1LIPECTSK | |
| SCHEMBL27760998 | 0.72 | EPHX1 (0.38) | SMN1; SMN2CTSLCTSBL3MBTL1LIPE | |
| SCHEMBL5190250 | 0.72 | USP2 (0.59) | USP2SMN1; SMN2CTSKMEN1MAPT | |
| SCHEMBL5651167 | 0.72 | LIPE (0.39) | CTSLCTSBL3MBTL1LIPECTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114437105-A | Inhibitors of receptor interacting protein kinase 1 | 戴纳立制药公司 | 2022-05-06 | — | — | CN | disclosed |
| CN-109071504-B | Inhibitors of receptor interacting protein kinase 1 | 戴纳立制药公司 | 2022-03-08 | — | — | CN | disclosed |